Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 1/20 | 0.46 |
| ▸ | BRAF | P15056 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 14/20 | 0.46 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.46 |
| ▸ | FBP1 | P09467 | 2/20 | 0.46 |
| ▸ | KDR | P35968 | 2/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | INSR | P06213 | 1/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | FLT4 | P35916 | 1/20 | 0.46 |
| ▸ | CLK1 | P49759 | 1/20 | 0.46 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.46 |
| ▸ | TEK | Q02763 | 1/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.46 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.43 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.42 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.41 |
| ▸ | DUS2 | Q9NX74 | 1/20 | 0.41 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.41 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6789229 | 0.88 | EGFR (0.46) | RAF1BRAFEGFRERBB2FBP1 | |
| SCHEMBL7848638 | 0.85 | EGFR (0.45) | RAF1BRAFEGFRERBB2FBP1 | |
| SCHEMBL7848647 | 0.85 | EGFR (0.45) | RAF1BRAFEGFRERBB2FBP1 | |
| SCHEMBL27595599 | 0.81 | MAT2A (0.42) | RAF1BRAF | |
| SCHEMBL5690020 | 0.79 | EGFR (0.65) | BRAFEGFRERBB2KDRPDGFRB | |
| SCHEMBL29737288 | 0.78 | EGFR (0.59) | EGFRERBB2ERBB4ERBB3 | |
| SCHEMBL7850414 | 0.78 | EGFR (0.49) | EGFRERBB2PDGFRBERBB4ERBB3 | |
| SCHEMBL27595568 | 0.77 | MAT2A (0.42) | RAF1BRAF | |
| SCHEMBL16986930 | 0.76 | EGFR (0.56) | EGFRERBB2ERBB4ERBB3 | |
| SCHEMBL3544316 | 0.75 | EGFR (0.55) | EGFRERBB2ERBB4ERBB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100404517-C | Bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and processes for their preparation | BOEHRINGER INGELHEIM PHARMA (DE) | 2008-07-23 | — | — | CN | disclosed |
| CN-1449390-A | Bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and processes for their preparation | BOEHRINGER INGELHEIM PHARMA (DE) | 2003-10-15 | — | — | CN | disclosed |