Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 15/20 | 0.56 |
| ▸ | ABCC8 | Q09428 | 15/20 | 0.56 |
| ▸ | KCNJ11 | Q14654 | 15/20 | 0.56 |
| ▸ | KCNJ8 | Q15842 | 15/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | CASP1 | P29466 | 3/20 | 0.55 |
| ▸ | CASP7 | P55210 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7101463 | 0.93 | ABCC9 (0.64) | ABCC9ABCC8KCNJ11KCNJ8HSD17B10 | |
| SCHEMBL6925767 | 0.87 | ABCC9 (0.66) | ABCC9ABCC8KCNJ11KCNJ8HSD17B10 | |
| SCHEMBL7095905 | 0.82 | ABCC9 (0.64) | ABCC9ABCC8KCNJ11KCNJ8ALDH1A1 | |
| SCHEMBL7852574 | 0.81 | ABCC9 (0.56) | ABCC9ABCC8KCNJ11KCNJ8KDM4E | |
| SCHEMBL5075485 | 0.81 | ABCC9 (0.68) | ABCC9ABCC8KCNJ11KCNJ8 | |
| Hydrochloric Acid SCHEMBL7097219 | 0.81 | ABCC9 (0.62) | ABCC9ABCC8KCNJ11KCNJ8ALDH1A1 | |
| SCHEMBL3325157 | 0.79 | KDM4E (0.70) | HSD17B10KDM4ECASP1CASP7ALDH1A1 | |
| SCHEMBL7097221 | 0.79 | ABCC9 (0.60) | ABCC9ABCC8KCNJ11KCNJ8ALDH1A1 | |
| SCHEMBL7575450 | 0.79 | ABCC9 (0.63) | ABCC9ABCC8KCNJ11KCNJ8HSD17B10 | |
| SCHEMBL7838750 | 0.78 | ABCC9 (0.62) | ABCC9ABCC8KCNJ11KCNJ8HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1131322-A2 | DIHYDROPYRIDINE COMPOUNDS AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2001-09-12 | — | — | EP | disclosed |
| WO-2000024741-A2 | DIHYDROPYRIDINE COMPOUNDS AND THEIR USE AS POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2000-05-04 | — | — | WO | disclosed |