Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7850718 | 0.87 | EDNRA (0.47) | EDNRAMAPTL3MBTL1PIK3CDPIK3CA | |
| SCHEMBL7850538 | 0.86 | MAPT (0.48) | EDNRAMAPTL3MBTL1PIK3CDPIK3CA | |
| SCHEMBL7853910 | 0.83 | EDNRA (0.50) | EDNRAMAPTL3MBTL1PIK3CDPIK3CA | |
| SCHEMBL7849633 | 0.83 | MAPT (0.47) | EDNRAMAPTL3MBTL1PIK3CDPIK3CA | |
| SCHEMBL7849615 | 0.78 | EDNRA (0.51) | EDNRAMAPTL3MBTL1PIK3CDPIK3CA | |
| SCHEMBL7008931 | 0.78 | EDNRA (0.74) | EDNRAMAPTKDM4EMAPK1ALDH1A1 | |
| SCHEMBL7011083 | 0.78 | MAPT (0.50) | EDNRAMAPTL3MBTL1PIK3CDPIK3CA | |
| SCHEMBL7850537 | 0.77 | EDNRA (0.49) | EDNRAMAPTL3MBTL1PIK3CDPIK3CA | |
| SCHEMBL7009897 | 0.76 | EDNRA (0.43) | EDNRAMAPTL3MBTL1PIK3CDPIK3CA | |
| SCHEMBL7009407 | 0.76 | MAPT (0.48) | EDNRAMAPTL3MBTL1PIK3CDPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0713875-B1 | Sulfonamides | HOFFMANN LA ROCHE (CH) | 2001-03-21 | — | — | EP | claimed |
| EP-0713875-A1 | Sulfonamides | F. Hoffmann-La Roche AG (CH) | 1996-05-29 | — | — | EP | claimed |
| WO-2001049289-A1 | PHARMACEUTICAL AND VETERINARY USES OF ENDOTHELIN ANTAGONISTS | TEXAS BIOTECHNOLOGY CORPORATION (US) | 2001-07-12 | — | — | WO | disclosed |