Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 5/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.39 |
| ▸ | NPC1 | O15118 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | AHR | P35869 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7848655 | 0.81 | CHRM2 (0.51) | GRM4KDM4ENPC1RAB9ACHRM2 | |
| SCHEMBL28428414 | 0.73 | CHRM2 (0.55) | GRM4KDM4ENPC1RAB9ACHRM2 | |
| SCHEMBL17687570 | 0.71 | CYP19A1 (0.64) | GRM4PDE4DKDM4ENPC1RAB9A | |
| SCHEMBL28061939 | 0.70 | NPC1 (0.56) | CYP3A4KDM4ENPC1RAB9AL3MBTL1 | |
| SCHEMBL27835461 | 0.70 | TNKS (0.54) | CYP3A4KDM4ENPC1RAB9ACYP19A1 | |
| SCHEMBL9430009 | 0.69 | CYP1B1 (0.50) | GRM4CYP3A4KDM4ENPC1RAB9A | |
| SCHEMBL13067678 | 0.68 | NPC1 (0.54) | KDM4ENPC1RAB9AL3MBTL1GPR55 | |
| SCHEMBL24776300 | 0.67 | KDM4E (0.54) | GRM4KDM4ENPC1RAB9AL3MBTL1 | |
| SCHEMBL25461188 | 0.67 | NPC1 (0.46) | CYP3A4KDM4ENPC1RAB9AL3MBTL1 | |
| SCHEMBL29923403 | 0.67 | PLAU (0.60) | CYP3A4KDM4ENPC1RAB9AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1136493-A1 | 2-(Thienopyridinyl)pyrimidone, 2-(furopyridinyl)pyrimidone 2-(isoquinolinyl)pyrimidone, 2-(pyridoindolyl)pyrimidone and 2-(benzofuropyridinyl)pyrimidone derivatives | SANOFI-SYNTHELABO (FR) | 2001-09-26 | — | — | EP | disclosed |