Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 1/20 | 0.97 |
| ▸ | JAK3 | P52333 | 6/20 | 0.74 |
| ▸ | AKT2 | P31751 | 4/20 | 0.67 |
| ▸ | GSK3B | P49841 | 3/20 | 0.67 |
| ▸ | KIT | P10721 | 2/20 | 0.67 |
| ▸ | LCK | P06239 | 1/20 | 0.65 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.62 |
| ▸ | DOT1L | Q8TEK3 | 2/20 | 0.57 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.56 |
| ▸ | AKT1 | P31749 | 3/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2251760 | 0.98 | HTR2C (1.00) | HTR2CJAK3AKT2GSK3BKIT | |
| Hydrochloric Acid SCHEMBL30012643 | 0.97 | HTR2C (0.97) | HTR2CJAK3AKT2GSK3BKIT | |
| Hydrochloric Acid SCHEMBL2794687 | 0.97 | HTR2C (0.97) | HTR2CJAK3AKT2GSK3BKIT | |
| Hydrochloric Acid SCHEMBL29036000 | 0.97 | HTR2C (0.97) | HTR2CJAK3AKT2GSK3BKIT | |
| SCHEMBL2024857 | 0.93 | HTR2C (0.89) | HTR2CJAK3AKT2GSK3BKIT | |
| Methylpiperazine SCHEMBL7852298 | 0.87 | HTR2C (0.79) | HTR2CJAK3AKT2GSK3BKIT | |
| SCHEMBL1818852 | 0.85 | JAK3 (1.00) | HTR2CJAK3AKT2GSK3BKIT | |
| SCHEMBL31550436 | 0.85 | JAK3 (0.93) | HTR2CJAK3AKT2GSK3BKIT | |
| Morpholine SCHEMBL7853772 | 0.84 | JAK3 (0.86) | HTR2CJAK3AKT2GSK3BKIT | |
| SCHEMBL3959075 | 0.84 | JAK3 (1.00) | HTR2CJAK3AKT2GSK3BKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1087971-A1 | PYRROLO 2,3-d]PYRIMIDINE COMPOUNDS | Pfizer Products Inc. (US) | 2001-04-04 | — | — | EP | disclosed |
| WO-1999065909-A1 | PYRROLO[2,3-d]PYRIMIDINE COMPOUNDS | PFIZER PRODUCTS INC. (US) | 1999-12-23 | — | — | WO | disclosed |