Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DOT1L | Q8TEK3 | 2/20 | 0.66 |
| ▸ | JAK3 | P52333 | 6/20 | 0.61 |
| ▸ | HTR2C | P28335 | 1/20 | 0.54 |
| ▸ | AKT2 | P31751 | 2/20 | 0.52 |
| ▸ | GSK3B | P49841 | 2/20 | 0.52 |
| ▸ | KIT | P10721 | 1/20 | 0.52 |
| ▸ | LCK | P06239 | 1/20 | 0.51 |
| ▸ | JAK2 | O60674 | 2/20 | 0.51 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.50 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.50 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.50 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.50 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.50 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.50 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.50 |
| ▸ | BTK | Q06187 | 5/20 | 0.49 |
| ▸ | JAK1 | P23458 | 1/20 | 0.48 |
| ▸ | TEC | P42680 | 1/20 | 0.47 |
| ▸ | TXK | P42681 | 1/20 | 0.47 |
| ▸ | BMX | P51813 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2020261 | 0.91 | DOT1L (0.74) | DOT1LJAK3HTR2CAKT2GSK3B | |
| SCHEMBL2019327 | 0.91 | DOT1L (0.74) | DOT1LJAK3HTR2CAKT2GSK3B | |
| SCHEMBL2019326 | 0.91 | DOT1L (0.74) | DOT1LJAK3HTR2CAKT2GSK3B | |
| SCHEMBL7852508 | 0.89 | JAK3 (0.60) | DOT1LJAK3HTR2CAKT2GSK3B | |
| SCHEMBL2021049 | 0.84 | JAK3 (0.71) | DOT1LJAK3HTR2CAKT2GSK3B | |
| SCHEMBL2021046 | 0.84 | JAK3 (0.71) | DOT1LJAK3HTR2CAKT2GSK3B | |
| SCHEMBL7850879 | 0.83 | DOT1L (0.60) | DOT1LJAK3HTR2CAKT2GSK3B | |
| SCHEMBL7855286 | 0.83 | JAK3 (0.83) | DOT1LJAK3HTR2CAKT2GSK3B | |
| SCHEMBL3953791 | 0.82 | DOT1L (0.59) | DOT1LJAK3HTR2CAKT2GSK3B | |
| SCHEMBL7851332 | 0.81 | PBK (0.60) | DOT1LJAK3HTR2CJAK2BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1087971-A1 | PYRROLO 2,3-d]PYRIMIDINE COMPOUNDS | Pfizer Products Inc. (US) | 2001-04-04 | — | — | EP | disclosed |
| WO-1999065909-A1 | PYRROLO[2,3-d]PYRIMIDINE COMPOUNDS | PFIZER PRODUCTS INC. (US) | 1999-12-23 | — | — | WO | disclosed |