Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.54 |
| ▸ | HAT1 | O14929 | 1/20 | 0.54 |
| ▸ | EP300 | Q09472 | 1/20 | 0.54 |
| ▸ | GFER | P55789 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7849756 | 0.87 | ALDH1A1 (0.67) | MAPTALDH1A1KDM4EL3MBTL1HPGD | |
| SCHEMBL7851242 | 0.84 | MAPT (0.64) | MAPTALDH1A1KDM4EL3MBTL1HPGD | |
| SCHEMBL7846817 | 0.82 | MAPT (0.78) | MAPTALDH1A1HPGDGAAGFER | |
| SCHEMBL8241650 | 0.81 | ALDH1A1 (0.85) | MAPTALDH1A1KDM4EL3MBTL1HPGD | |
| SCHEMBL7857046 | 0.81 | MAPT (0.62) | MAPTALDH1A1KDM4EL3MBTL1HPGD | |
| SCHEMBL3813968 | 0.81 | MAPT (0.68) | MAPTALDH1A1KDM4EL3MBTL1HPGD | |
| SCHEMBL7846928 | 0.80 | GFER (0.80) | MAPTALDH1A1HPGDGAAGFER | |
| SCHEMBL3808616 | 0.79 | ALDH1A1 (0.65) | MAPTALDH1A1KDM4EL3MBTL1HPGD | |
| SCHEMBL26616624 | 0.78 | MAPT (0.67) | MAPTALDH1A1KDM4EL3MBTL1HPGD | |
| SCHEMBL26616376 | 0.78 | MAPT (0.67) | MAPTALDH1A1KDM4EL3MBTL1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140914-A1 | NON-PEPTIDE NK1 RECEPTORS ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000037462-A1 | NON-PEPTIDE NK1 RECEPTORS ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 2000-06-29 | — | — | WO | disclosed |