Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRP | O00591 | 3/20 | 0.60 |
| ▸ | GABRD | O14764 | 3/20 | 0.60 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.60 |
| ▸ | GABRB1 | P18505 | 3/20 | 0.60 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.60 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.60 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.60 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.60 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.60 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.60 |
| ▸ | GABRA4 | P48169 | 3/20 | 0.60 |
| ▸ | GABRE | P78334 | 3/20 | 0.60 |
| ▸ | GABRA6 | Q16445 | 3/20 | 0.60 |
| ▸ | GABRG1 | Q8N1C3 | 3/20 | 0.60 |
| ▸ | GABRG3 | Q99928 | 3/20 | 0.60 |
| ▸ | GABRQ | Q9UN88 | 3/20 | 0.60 |
| ▸ | HTR1B | P28222 | 8/20 | 0.59 |
| ▸ | HTR1A | P08908 | 2/20 | 0.59 |
| ▸ | HTR1D | P28221 | 6/20 | 0.56 |
| ▸ | HTR6 | P50406 | 6/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7853144 | 1.00 | GABRP (0.60) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL31670929 | 0.87 | HTR1B (0.78) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL8885771 | 0.87 | HTR1B (0.59) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL1122175 | 0.85 | HTR1B (0.76) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL1122542 | 0.85 | HTR1B (0.76) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL1122165 | 0.85 | HTR1B (0.76) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL7850277 | 0.84 | GABRP (0.61) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL7850275 | 0.84 | GABRP (0.61) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL7808656 | 0.83 | GABRP (0.65) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL8979690 | 0.82 | GABRP (0.53) | GABRPGABRDGABRA1GABRB1GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0666858-B1 | 5-ARYLINDOLE DERIVATIVES AND THEIR USE AS SEROTONIN (5-HT 1) AGONISTS | PFIZER (US) | 2001-06-13 | — | — | EP | disclosed |
| EP-1094064-A1 | 5-arylindolederivatives and their use as serotonin(5-ht1)agonists | PFIZER INC. (US) | 2001-04-25 | — | — | EP | disclosed |
| US-5886008-A | 5-arylindole derivatives | PFIZER INC. (US) | 1999-03-23 | — | — | US | disclosed |