Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT2 | P31751 | 3/20 | 0.58 |
| ▸ | GSK3B | P49841 | 2/20 | 0.58 |
| ▸ | HTR2C | P28335 | 1/20 | 0.57 |
| ▸ | KIT | P10721 | 2/20 | 0.55 |
| ▸ | LCK | P06239 | 1/20 | 0.54 |
| ▸ | JAK3 | P52333 | 8/20 | 0.51 |
| ▸ | JAK2 | O60674 | 3/20 | 0.51 |
| ▸ | JAK1 | P23458 | 3/20 | 0.51 |
| ▸ | TYK2 | P29597 | 3/20 | 0.51 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.48 |
| ▸ | BTK | Q06187 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3957905 | 0.95 | AKT2 (0.65) | AKT2GSK3BHTR2CKITLCK | |
| SCHEMBL7852543 | 0.87 | AKT2 (0.63) | AKT2GSK3BHTR2CKITLCK | |
| SCHEMBL7843601 | 0.83 | AKT2 (0.66) | AKT2GSK3BHTR2CKITLCK | |
| SCHEMBL2048915 | 0.81 | AKT2 (0.70) | AKT2GSK3BHTR2CKITLCK | |
| SCHEMBL3955148 | 0.77 | AKT2 (0.74) | AKT2GSK3BHTR2CKITLCK | |
| SCHEMBL4125661 | 0.75 | AKT2 (1.00) | AKT2GSK3BHTR2CKITLCK | |
| SCHEMBL7843600 | 0.75 | AKT2 (0.57) | AKT2GSK3BHTR2CKITLCK | |
| SCHEMBL2251760 | 0.74 | HTR2C (1.00) | AKT2GSK3BHTR2CKITLCK | |
| SCHEMBL82734 | 0.74 | GBA1 (0.61) | — | |
| SCHEMBL2022114 | 0.74 | AKT2 (0.69) | AKT2GSK3BHTR2CKITLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1087971-A1 | PYRROLO 2,3-d]PYRIMIDINE COMPOUNDS | Pfizer Products Inc. (US) | 2001-04-04 | — | — | EP | disclosed |
| WO-1999065909-A1 | PYRROLO[2,3-d]PYRIMIDINE COMPOUNDS | PFIZER PRODUCTS INC. (US) | 1999-12-23 | — | — | WO | disclosed |