Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.59 |
| ▸ | HTR1A | P08908 | 11/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.46 |
| ▸ | DRD2 | P14416 | 4/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.46 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7853405 | 1.00 | HSD11B1 (0.59) | HSD11B1HTR1AADRA2AADRA1AADRA1B | |
| SCHEMBL8143314 | 1.00 | HSD11B1 (0.59) | HSD11B1HTR1AADRA2AADRA1AADRA1B | |
| SCHEMBL8136238 | 1.00 | HSD11B1 (0.59) | HSD11B1HTR1AADRA2AADRA1AADRA1B | |
| SCHEMBL7853400 | 1.00 | HSD11B1 (0.59) | HSD11B1HTR1AADRA2AADRA1AADRA1B | |
| Hydrochloric Acid SCHEMBL7851354 | 0.99 | HSD11B1 (0.58) | HSD11B1HTR1AADRA2AADRA1AADRA1B | |
| Hydrochloric Acid SCHEMBL10835594 | 0.99 | HSD11B1 (0.58) | HSD11B1HTR1AADRA2AADRA1AADRA1B | |
| Hydrochloric Acid SCHEMBL8142920 | 0.99 | HSD11B1 (0.58) | HSD11B1HTR1AADRA2AADRA1AADRA1B | |
| SCHEMBL10504998 | 0.84 | PARP1 (0.42) | HSD11B1ADRA1AADRA1B | |
| Hydrochloric Acid SCHEMBL7841041 | 0.83 | HSD11B1 (0.42) | HSD11B1HTR1AADRA2AADRA1AADRA1B | |
| Hydrochloric Acid SCHEMBL10835960 | 0.83 | PARP1 (0.41) | HSD11B1ADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0805812-B1 | BICYCLIC SUBSTITUTED HEXAHYDROBENZ(E)ISOINDOLE ALPHA-1- ADRENERGIC ANTAGONISTS | ABBOTT LAB (US) | 2001-06-13 | — | — | EP | disclosed |
| WO-1996022991-A1 | BICYCLIC SUBSTITUTED HEXAHYDROBENZ[E]ISOINDOLE ALPHA-1- ADRENERGIC ANTAGONISTS | ABBOTT LABORATORIES (US) | 1996-08-01 | — | — | WO | disclosed |
| WO-1996022992-A1 | TRICYCLIC SUBSTITUTED HEXAHYDROBENZ[E]ISOINDOLE ALPHA-1 ADRENERGIC ANTAGONISTS | ABBOTT LABORATORIES (US) | 1996-08-01 | — | — | WO | disclosed |
| US-5521181-A | Bicyclic substituted hexahydrobenz[e]isoindole α-1 adrenergic antagonists | ABBOTT LABORATORIES (US) | 1996-05-28 | — | — | US | disclosed |