Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27638670 | 0.83 | ALDH1A1 (0.40) | SMN1; SMN2TSHRHTTMEN1KMT2A | |
| SCHEMBL1239686 | 0.81 | KCNA5 (0.53) | TSHRHTTALDH1A1LMNACYP2C9 | |
| SCHEMBL27569069 | 0.78 | ALDH1A1 (0.39) | SMN1; SMN2TSHRALDH1A1CYP2C19GRM5 | |
| SCHEMBL15797503 | 0.77 | DPP4 (0.53) | SMN1; SMN2ADRB2TSHRHTTALDH1A1 | |
| SCHEMBL15797501 | 0.75 | TSHR (0.59) | SMN1; SMN2ADRB2TSHRHTTALDH1A1 | |
| SCHEMBL11504155 | 0.74 | GRM5 (0.46) | SMN1; SMN2ADRB2TSHRHTTMEN1 | |
| SCHEMBL5028997 | 0.74 | SMN1; SMN2 (0.42) | SMN1; SMN2ADRB2TSHRHTTMEN1 | |
| SCHEMBL15797437 | 0.74 | ALDH1A1 (0.72) | SMN1; SMN2ADRB2TSHRHTTMEN1 | |
| SCHEMBL27845240 | 0.73 | ALDH1A1 (0.44) | SMN1; SMN2TSHRKMT2AALDH1A1MAPT | |
| SCHEMBL11989196 | 0.71 | MAPT (0.47) | SMN1; SMN2ADRB2TSHRHTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140851-A1 | 4-OXO-1,4-DIHYDRO-3-QUINOLINECARBOXAMIDES AS ANTIVIRAL AGENTS | PHARMACIA & UPJOHN COMPANY (US) | 2001-10-10 | — | — | EP | claimed |
| US-6248736-B1 | DNA POLYMERASE INHIBITORS EFFECTIVE AGAINST HERPESVIRUSES | PHARMACIA & UPJOHN COMPANY | 2001-06-19 | — | — | US | claimed |
| WO-2000040563-A1 | 4-OXO-1,4-DIHYDRO-3-QUINOLINECARBOXAMIDES AS ANTIVIRAL AGENTS | PHARMACIA & UPJOHN COMPANY (US) | 2000-07-13 | — | — | WO | claimed |