Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STK3 | Q13188 | 7/20 | 0.71 |
| ▸ | STK4 | Q13043 | 6/20 | 0.71 |
| ▸ | LRRK2 | Q5S007 | 17/20 | 0.64 |
| ▸ | CDC7 | O00311 | 1/20 | 0.63 |
| ▸ | ROS1 | P08922 | 1/20 | 0.63 |
| ▸ | KIT | P10721 | 1/20 | 0.63 |
| ▸ | MARK3 | P27448 | 1/20 | 0.63 |
| ▸ | FLT3 | P36888 | 1/20 | 0.63 |
| ▸ | CDK8 | P49336 | 1/20 | 0.63 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.63 |
| ▸ | MAP3K10 | Q02779 | 1/20 | 0.63 |
| ▸ | MELK | Q14680 | 1/20 | 0.63 |
| ▸ | MARK4 | Q96L34 | 1/20 | 0.63 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.63 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.63 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3960587 | 0.94 | STK3 (0.80) | STK3STK4LRRK2CDC7ROS1 | |
| Piperidine SCHEMBL7850952 | 0.84 | STK3 (0.71) | STK3STK4LRRK2CDC7ROS1 | |
| SCHEMBL31301646 | 0.83 | STK4 (1.00) | STK3STK4LRRK2 | |
| Piperidine SCHEMBL7850926 | 0.80 | LRRK2 (0.71) | STK3STK4LRRK2CDC7ROS1 | |
| Piperidine SCHEMBL7850291 | 0.80 | LRRK2 (0.70) | STK3STK4LRRK2CDC7ROS1 | |
| Piperidine SCHEMBL7851635 | 0.79 | LRRK2 (0.66) | STK3STK4LRRK2CDC7ROS1 | |
| SCHEMBL3535044 | 0.78 | LRRK2 (1.00) | STK3STK4LRRK2CDC7ROS1 | |
| SCHEMBL15402600 | 0.78 | LRRK2 (1.00) | STK3STK4LRRK2CDC7ROS1 | |
| SCHEMBL4298450 | 0.77 | AKT1 (0.64) | STK3STK4LRRK2CDC7ROS1 | |
| SCHEMBL3959268 | 0.77 | STK3 (0.80) | STK3STK4LRRK2CDC7ROS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1087971-A1 | PYRROLO 2,3-d]PYRIMIDINE COMPOUNDS | Pfizer Products Inc. (US) | 2001-04-04 | — | — | EP | disclosed |
| WO-1999065909-A1 | PYRROLO[2,3-d]PYRIMIDINE COMPOUNDS | PFIZER PRODUCTS INC. (US) | 1999-12-23 | — | — | WO | disclosed |