Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 12/20 | 0.63 |
| ▸ | MAPK11 | Q15759 | 11/20 | 0.63 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.42 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.42 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.42 |
| ▸ | RAF1 | P04049 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.39 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.39 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | IKBKB | O14920 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5260860 | 0.84 | MAPK11 (0.76) | MAPK14MAPK11MAPK13MAPK9MAPK12 | |
| Hydrochloric Acid SCHEMBL5259077 | 0.83 | MAPK11 (0.74) | MAPK14MAPK11MAPK13MAPK9MAPK12 | |
| SCHEMBL5259318 | 0.77 | MAPK11 (1.00) | MAPK14MAPK11 | |
| SCHEMBL5258174 | 0.77 | MAPK11 (0.75) | MAPK14MAPK11MAPK13MAPK9MAPK12 | |
| SCHEMBL5259009 | 0.77 | MAPK11 (0.74) | MAPK14MAPK11MAPK13MAPK9MAPK12 | |
| SCHEMBL5259004 | 0.77 | MAPK11 (0.74) | MAPK14MAPK11MAPK13MAPK9MAPK12 | |
| SCHEMBL5257383 | 0.71 | MAPK11 (0.78) | MAPK14MAPK11MAPK13MAPK9MAPK12 | |
| Hydrochloric Acid SCHEMBL5257534 | 0.71 | MAPK11 (0.76) | MAPK14MAPK11MAPK13MAPK9MAPK12 | |
| SCHEMBL23873173 | 0.70 | HTR2C (0.60) | — | |
| SCHEMBL26115367 | 0.70 | HTR2C (0.60) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1144403-A1 | SUBSTITUED PYRAZOLES AS P38 KINASE INHIBITORS | G.D. SEARLE & CO. (US) | 2001-10-17 | — | — | EP | disclosed |
| WO-2000031063-A1 | SUBSTITUTED PYRAZOLES AS p38 KINASE INHIBITORS | G.D. SEARLE & CO. (US) | 2000-06-02 | — | — | WO | disclosed |