Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 7/20 | 0.60 |
| ▸ | HTR2A | P28223 | 5/20 | 0.56 |
| ▸ | HTR2B | P41595 | 5/20 | 0.56 |
| ▸ | HTR1A | P08908 | 1/20 | 0.53 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.45 |
| ▸ | AKT1 | P31749 | 3/20 | 0.45 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.43 |
| ▸ | IDH2 | P48735 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26115367 | 1.00 | HTR2C (0.60) | HTR2CHTR2AHTR2BHTR1AP2RY14 | |
| SCHEMBL26515976 | 1.00 | HTR2C (0.60) | HTR2CHTR2AHTR2BHTR1AP2RY14 | |
| SCHEMBL14635814 | 0.84 | HTR2C (0.42) | HTR2CHTR2AHTR2BHTR1AP2RY14 | |
| SCHEMBL2664692 | 0.83 | HTR2C (0.60) | HTR2CHTR2AHTR2BHTR1AAKT1 | |
| SCHEMBL22958179 | 0.82 | P2RY14 (0.56) | HTR2CHTR2AHTR2BP2RY14AKT1 | |
| SCHEMBL26516042 | 0.82 | P2RY14 (0.56) | HTR2CHTR2AHTR2BP2RY14AKT1 | |
| SCHEMBL26114096 | 0.82 | P2RY14 (0.56) | HTR2CHTR2AHTR2BP2RY14AKT1 | |
| Hydrochloric Acid SCHEMBL6439125 | 0.82 | HTR2C (0.61) | HTR2CHTR2AHTR2BHTR1AAKT1 | |
| Hydrochloric Acid SCHEMBL6961922 | 0.82 | HTR2C (0.61) | HTR2CHTR2AHTR2BHTR1AAKT1 | |
| Hydrochloric Acid SCHEMBL6439127 | 0.82 | HTR2C (0.61) | HTR2CHTR2AHTR2BHTR1AAKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240092781-A1 | ARYL PIPERIDINES AS MONOACYLGLYCEROL LIPASE MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2024-03-21 | — | — | US | disclosed |
| US-11787798-B2 | Aryl piperidines as monoacylglycerol lipase modulators | JANSSEN PHARMACEUTICA NV (BE) | 2023-10-17 | — | — | US | disclosed |
| CN-115362151-A | Aryl piperidines as monoacylglycerol lipase modulators | 詹森药业有限公司 | 2022-11-18 | — | — | CN | disclosed |
| WO-2021191384-A1 | ARYL PIPERIDINES AS MONOACYLGLYCEROL LIPASE MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2021-09-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240092781-A1 | ARYL PIPERIDINES AS MONOACYLGLYCEROL LIPASE MODULATORS | MGLL, LPL, PNLIP | HTR2C 64/4885HTR2A 26/4885HTR2B 38/4885 |
| US-11787798-B2 | Aryl piperidines as monoacylglycerol lipase modulators | MGLL, LPL, PNLIP | HTR2C 64/4885HTR2A 26/4885HTR2B 38/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.