Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.47 |
| ▸ | CCR2 | P41597 | 11/20 | 0.46 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.42 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.42 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | F10 | P00742 | 2/20 | 0.40 |
| ▸ | PTGES | O14684 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5215529 | 0.81 | CCR2 (0.53) | SMN1; SMN2LMNAGAAMAPTHTT | |
| SCHEMBL5213680 | 0.77 | CCR2 (0.65) | SMN1; SMN2LMNAGAAMAPTHTT | |
| SCHEMBL5214927 | 0.76 | CCR2 (0.59) | SMN1; SMN2LMNAGAAMAPTHTT | |
| SCHEMBL8688955 | 0.76 | CCR2 (0.59) | SMN1; SMN2LMNAGAAMAPTHTT | |
| SCHEMBL5216535 | 0.76 | CCR2 (0.59) | SMN1; SMN2LMNAGAAMAPTHTT | |
| SCHEMBL5219665 | 0.76 | CCR2 (0.56) | SMN1; SMN2LMNAGAAMAPTHTT | |
| SCHEMBL6302584 | 0.75 | CCR2 (0.62) | SMN1; SMN2LMNAGAAMAPTHTT | |
| SCHEMBL5214863 | 0.75 | CCR2 (0.76) | SMN1; SMN2LMNAGAAMAPTHTT | |
| SCHEMBL5213262 | 0.74 | CCR2 (0.57) | SMN1; SMN2LMNAGAAMAPTHTT | |
| SCHEMBL5216641 | 0.74 | MEN1 (0.63) | SMN1; SMN2LMNAGAAMAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1150953-A1 | INDOLE DERIVATIVES AND THEIR USE AS MCP-1 RECEPTOR ANTAGONISTS | AstraZeneca AB (SE) | 2001-11-07 | — | — | EP | disclosed |
| WO-2000046197-A1 | INDOLE DERIVATIVES AND THEIR USE AS MCP-1 RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2000-08-10 | — | — | WO | disclosed |