Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTBK1 | Q5TCY1 | 7/20 | 0.47 |
| ▸ | TTBK2 | Q6IQ55 | 6/20 | 0.47 |
| ▸ | AKT1 | P31749 | 5/20 | 0.44 |
| ▸ | AKT2 | P31751 | 2/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7589835 | 0.72 | TTBK1 (0.57) | TTBK1TTBK2AKT1AKT2ROCK2 | |
| SCHEMBL7855768 | 0.71 | TTBK1 (0.43) | TTBK1TTBK2AKT1AKT2ROCK2 | |
| SCHEMBL7855770 | 0.70 | TTBK1 (0.43) | TTBK1TTBK2AKT1AKT2ROCK2 | |
| SCHEMBL7589837 | 0.66 | TTBK1 (0.48) | TTBK1TTBK2AKT1AKT2ROCK2 | |
| SCHEMBL24881245 | 0.64 | TTBK1 (1.00) | TTBK1TTBK2 | |
| SCHEMBL29748913 | 0.64 | TTBK1 (0.49) | TTBK1TTBK2RET | |
| SCHEMBL7087720 | 0.64 | TTBK1 (0.55) | TTBK1TTBK2 | |
| SCHEMBL11105507 | 0.63 | AKT1 (0.44) | AKT1 | |
| SCHEMBL1899427 | 0.62 | TTBK1 (1.00) | TTBK1TTBK2 | |
| SCHEMBL3534019 | 0.62 | TTBK1 (0.49) | TTBK1TTBK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1087970-A1 | PYRROLO 2,3-d]PYRIMIDINE COMPOUNDS | Pfizer Products Inc. (US) | 2001-04-04 | — | — | EP | disclosed |
| WO-1999065908-A1 | PYRROLO[2,3-d]PYRIMIDINE COMPOUNDS | PFIZER PRODUCTS INC. (US) | 1999-12-23 | — | — | WO | disclosed |