Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.61 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.57 |
| ▸ | HTR2A | P28223 | 16/20 | 0.55 |
| ▸ | HTR2C | P28335 | 15/20 | 0.55 |
| ▸ | HTR2B | P41595 | 2/20 | 0.52 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.49 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7680234 | 0.99 | MAPKAPK2 (0.63) | MAPKAPK2SIRT1HTR2AHTR2CHTR2B | |
| SCHEMBL7680308 | 0.97 | MAPKAPK2 (0.63) | MAPKAPK2SIRT1HTR2AHTR2CHTR2B | |
| SCHEMBL7843268 | 0.87 | SIRT1 (0.64) | MAPKAPK2SIRT1HTR2AHTR2CHTR2B | |
| Hydrochloric Acid SCHEMBL7680976 | 0.86 | SIRT1 (0.62) | MAPKAPK2SIRT1HTR2AHTR2CHTR2B | |
| SCHEMBL7695296 | 0.85 | MAPKAPK2 (0.59) | MAPKAPK2SIRT1HTR2AHTR2CHTR2B | |
| SCHEMBL7851653 | 0.84 | MAPKAPK2 (0.62) | MAPKAPK2SIRT1HTR2AHTR2C | |
| Hydrochloric Acid SCHEMBL7697449 | 0.84 | KMT2A (0.55) | MAPKAPK2SIRT1HTR2AHTR2CHTR2B | |
| SCHEMBL7680835 | 0.84 | HTR2A (0.56) | MAPKAPK2SIRT1HTR2AHTR2CHTR2B | |
| SCHEMBL7680354 | 0.83 | HTR2A (0.47) | MAPKAPK2SIRT1HTR2AHTR2CHTR2B | |
| SCHEMBL7680950 | 0.83 | SIRT1 (0.54) | MAPKAPK2SIRT1HTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1070716-A1 | Beta-carboline derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 2001-01-24 | — | — | EP | disclosed |