Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 10/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 6/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | TYK2 | P29597 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7023035 | 0.78 | CYP1A2 (0.39) | ADORA1ADORA2ASMN1; SMN2CYP1A2CYP3A4 | |
| SCHEMBL7855999 | 0.77 | ASIC3 (0.44) | KMT2AADORA1ADORA2ASMN1; SMN2RPS6KA3 | |
| SCHEMBL15587042 | 0.75 | NISCH (0.63) | ADORA1ADORA2ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7856164 | 0.71 | CSNK1A1 (0.43) | KMT2AADORA1ADORA2ANISCH | |
| SCHEMBL4971068 | 0.71 | MAP3K14 (0.49) | KMT2AADORA1ADORA2ALMNAMAPT | |
| SCHEMBL7853495 | 0.71 | GSK3B (0.46) | — | |
| SCHEMBL7023251 | 0.71 | GSK3B (0.46) | — | |
| SCHEMBL5089143 | 0.71 | GSK3B (0.52) | — | |
| SCHEMBL4972846 | 0.70 | GSK3B (0.52) | KMT2AADORA1ADORA2ARPS6KA3LMNA | |
| SCHEMBL27559815 | 0.68 | GSK3B (0.42) | KMT2AADORA1CYP1A2MEN1P2RX3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1312807-A | Inhibitors of glycogen synthase kinase 3 | CHIRON CORP (US) | 2001-09-12 | — | — | CN | disclosed |
| EP-1087963-A1 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | Chiron Corporation (US) | 2001-04-04 | — | — | EP | disclosed |
| WO-1999065897-A1 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 1999-12-23 | — | — | WO | disclosed |