Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.39 |
| ▸ | RAB9A | P51151 | 5/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.36 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 4/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 3/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5094009 | 0.88 | MAPT (0.44) | MAPTRAB9AKDM4ENPC1SMN1; SMN2 | |
| SCHEMBL5092303 | 0.78 | MAPT (0.51) | MAPTRAB9AKDM4ENPC1SMN1; SMN2 | |
| SCHEMBL5094666 | 0.77 | MAPT (0.49) | MAPTRAB9AKDM4ENPC1SMN1; SMN2 | |
| SCHEMBL5092017 | 0.76 | RAB9A (0.48) | MAPTRAB9AKDM4ENPC1SMN1; SMN2 | |
| SCHEMBL5093391 | 0.76 | MAPT (0.48) | MAPTRAB9AKDM4ENPC1SMN1; SMN2 | |
| SCHEMBL5089131 | 0.76 | MAPT (0.46) | MAPTRAB9AKDM4ENPC1SMN1; SMN2 | |
| SCHEMBL5092467 | 0.76 | MAPT (0.50) | MAPTRAB9AKDM4ENPC1SMN1; SMN2 | |
| SCHEMBL5094456 | 0.76 | GSK3B (0.49) | MAPTRAB9AKDM4ENPC1SMN1; SMN2 | |
| SCHEMBL5089344 | 0.76 | MAPT (0.48) | MAPTRAB9AKDM4ENPC1SMN1; SMN2 | |
| SCHEMBL5091542 | 0.76 | MAPT (0.48) | MAPTRAB9AKDM4ENPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1087963-A1 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | Chiron Corporation (US) | 2001-04-04 | — | — | EP | disclosed |
| WO-1999065897-A1 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 1999-12-23 | — | — | WO | disclosed |