Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNK3 | O14649 | 5/20 | 0.50 |
| ▸ | KCNK9 | Q9NPC2 | 4/20 | 0.50 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.50 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | PARP1 | P09874 | 2/20 | 0.46 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.46 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7856433 | 0.90 | ITGB3 (0.54) | KCNK3KCNK9ITGB3ITGA2BKMT2A | |
| SCHEMBL7856436 | 0.85 | ITGB3 (0.48) | KCNK3KCNK9ITGB3ITGA2BKMT2A | |
| SCHEMBL7856438 | 0.84 | CASR (0.49) | KCNK3KCNK9KMT2APOLBMEN1 | |
| SCHEMBL7455765 | 0.84 | ITGB3 (0.58) | KCNK3KCNK9ITGB3ITGA2BKMT2A | |
| SCHEMBL2839379 | 0.82 | MAPK1 (0.55) | KCNK3KCNK9ITGB3ITGA2BKMT2A | |
| SCHEMBL2837451 | 0.82 | ITGB3 (0.62) | KCNK3KCNK9ITGB3ITGA2B | |
| SCHEMBL2838433 | 0.81 | ITGB3 (0.60) | ITGB3ITGA2BKMT2APOLBMEN1 | |
| SCHEMBL2836646 | 0.81 | MEN1 (0.47) | KCNK3KCNK9ITGB3ITGA2BKMT2A | |
| SCHEMBL2833499 | 0.81 | KMT2A (0.53) | KCNK3KCNK9ITGB3ITGA2BKMT2A | |
| SCHEMBL2837526 | 0.80 | KMT2A (0.49) | ITGB3ITGA2BKMT2APOLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0889877-B1 | META-SUBSTITUTED PHENYLENE DERIVATIVES AND THEIR USE AS ALPHAvBETA3 INTEGRIN ANTAGONISTS OR INHIBITORS | SEARLE & CO (US) | 2001-08-29 | — | — | EP | claimed |
| EP-0889877-B1 | META-SUBSTITUTED PHENYLENE DERIVATIVES AND THEIR USE AS ALPHAvBETA3 INTEGRIN ANTAGONISTS OR INHIBITORS | SEARLE & CO (US) | 2001-08-29 | — | — | EP | disclosed |