Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 18/20 | 0.51 |
| ▸ | FGFR4 | P22455 | 12/20 | 0.51 |
| ▸ | FGFR2 | P21802 | 10/20 | 0.51 |
| ▸ | KDR | P35968 | 10/20 | 0.51 |
| ▸ | FGFR3 | P22607 | 9/20 | 0.51 |
| ▸ | FLT1 | P17948 | 4/20 | 0.46 |
| ▸ | FLT4 | P35916 | 4/20 | 0.46 |
| ▸ | SRC | P12931 | 4/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7848265 | 0.84 | FGFR1 (0.48) | FGFR1FGFR4FGFR2KDRFGFR3 | |
| SCHEMBL3977664 | 0.83 | FGFR4 (0.54) | FGFR1FGFR4FGFR2KDRFGFR3 | |
| SCHEMBL3967361 | 0.81 | FGFR4 (0.53) | FGFR1FGFR4FGFR2KDRFGFR3 | |
| SCHEMBL3972066 | 0.80 | FGFR4 (0.52) | FGFR1FGFR4FGFR2KDRFGFR3 | |
| SCHEMBL7858279 | 0.79 | FGFR1 (0.50) | FGFR1FGFR4FGFR2KDRFGFR3 | |
| SCHEMBL3970540 | 0.77 | FGFR4 (0.46) | FGFR1FGFR4FGFR2KDRFGFR3 | |
| SCHEMBL16894019 | 0.76 | FGFR4 (0.48) | FGFR1FGFR4FGFR2KDRFGFR3 | |
| SCHEMBL3979713 | 0.75 | FGFR4 (0.52) | FGFR1FGFR4FGFR2KDRFGFR3 | |
| SCHEMBL7857067 | 0.73 | FGFR4 (0.45) | FGFR1FGFR4FGFR2KDRFGFR3 | |
| SCHEMBL3974703 | 0.73 | FGFR4 (0.51) | FGFR1FGFR4FGFR2KDRFGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1080092-A2 | BICYCLIC PYRIMIDINES AND BICYCLIC 3,4-DIHYDROPYRIMIDINES AS INHIBITORS OF CELLULAR PROLIFERATION | WARNER-LAMBERT COMPANY (US) | 2001-03-07 | — | — | EP | disclosed |
| WO-1999061444-A2 | BICYCLIC PYRIMIDINES AND BICYCLIC 3,4-DIHYDROPYRIMIDINES AS INHIBITORS OF CELLULAR PROLIFERATION | WARNER-LAMBERT COMPANY (US) | 1999-12-02 | — | — | WO | disclosed |