Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 17/20 | 0.48 |
| ▸ | FGFR4 | P22455 | 12/20 | 0.48 |
| ▸ | FGFR2 | P21802 | 9/20 | 0.48 |
| ▸ | FGFR3 | P22607 | 8/20 | 0.48 |
| ▸ | KDR | P35968 | 8/20 | 0.48 |
| ▸ | FLT1 | P17948 | 4/20 | 0.43 |
| ▸ | FLT4 | P35916 | 4/20 | 0.43 |
| ▸ | SRC | P12931 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7856512 | 0.84 | FGFR1 (0.51) | FGFR1FGFR4FGFR2FGFR3KDR | |
| SCHEMBL3969871 | 0.83 | FGFR4 (0.52) | FGFR1FGFR4FGFR2FGFR3KDR | |
| SCHEMBL3972876 | 0.81 | FGFR4 (0.49) | FGFR1FGFR4FGFR2FGFR3KDR | |
| SCHEMBL3970540 | 0.77 | FGFR4 (0.46) | FGFR1FGFR4FGFR2FGFR3KDR | |
| SCHEMBL3971289 | 0.76 | FGFR4 (0.51) | FGFR1FGFR4FGFR2FGFR3KDR | |
| SCHEMBL16894019 | 0.76 | FGFR4 (0.48) | FGFR1FGFR4FGFR2FGFR3KDR | |
| SCHEMBL3968941 | 0.73 | FGFR4 (0.51) | FGFR1FGFR4FGFR2FGFR3KDR | |
| SCHEMBL3971418 | 0.73 | FGFR4 (0.52) | FGFR1FGFR4FGFR2FGFR3KDR | |
| SCHEMBL3972202 | 0.73 | FGFR4 (0.51) | FGFR1FGFR4FGFR2FGFR3KDR | |
| SCHEMBL7857067 | 0.73 | FGFR4 (0.45) | FGFR1FGFR4FGFR2FGFR3KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1080092-A2 | BICYCLIC PYRIMIDINES AND BICYCLIC 3,4-DIHYDROPYRIMIDINES AS INHIBITORS OF CELLULAR PROLIFERATION | WARNER-LAMBERT COMPANY (US) | 2001-03-07 | — | — | EP | disclosed |
| WO-1999061444-A2 | BICYCLIC PYRIMIDINES AND BICYCLIC 3,4-DIHYDROPYRIMIDINES AS INHIBITORS OF CELLULAR PROLIFERATION | WARNER-LAMBERT COMPANY (US) | 1999-12-02 | — | — | WO | disclosed |