Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 15/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.38 |
| ▸ | OTUD7B | Q6GQQ9 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7856996 | 1.00 | HRH3 (0.40) | HRH3KCNH2MCHR1OTUD7BCYP2D6 | |
| SCHEMBL7858469 | 1.00 | HRH3 (0.40) | HRH3KCNH2MCHR1OTUD7BCYP2D6 | |
| SCHEMBL7856633 | 1.00 | HRH3 (0.40) | HRH3KCNH2MCHR1OTUD7BCYP2D6 | |
| SCHEMBL863982 | 1.00 | HRH3 (0.40) | HRH3KCNH2MCHR1OTUD7BCYP2D6 | |
| SCHEMBL863601 | 0.97 | HRH3 (0.40) | HRH3KCNH2OTUD7BCYP2D6 | |
| SCHEMBL863414 | 0.96 | HRH3 (0.38) | HRH3KCNH2MCHR1OTUD7B | |
| SCHEMBL863725 | 0.93 | OTUD7B (0.37) | HRH3KCNH2MCHR1OTUD7B | |
| SCHEMBL863544 | 0.92 | HRH3 (0.42) | HRH3KCNH2CYP2D6 | |
| SCHEMBL863455 | 0.92 | KCNH2 (0.45) | HRH3KCNH2CYP2D6 | |
| SCHEMBL864143 | 0.92 | HRH3 (0.44) | HRH3KCNH2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010144571-A1 | HISTAMINE H3 INVERSE AGONISTS AND ANTAGONISTS AND METHODS OF USE THEREOF | SEPRACOR INC. (US) | 2010-12-16 | — | — | WO | disclosed |