Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 19/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.80 |
| ▸ | HTR2B | P41595 | 1/20 | 0.80 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.80 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15942032 | 0.89 | GRM4 (1.00) | GRM4KCNH2HTR2BMTNR1A | |
| SCHEMBL18292374 | 0.84 | GRM4 (0.74) | GRM4KCNH2HTR2BMTNR1A | |
| SCHEMBL2710540 | 0.83 | GRM4 (0.77) | GRM4KCNH2HTR2BMTNR1A | |
| SCHEMBL28199101 | 0.82 | GRM4 (0.85) | GRM4KCNH2HTR2BMTNR1A | |
| SCHEMBL17125376 | 0.79 | GRM4 (0.67) | GRM4KCNH2HTR2BMTNR1A | |
| SCHEMBL31014179 | 0.78 | GRM4 (0.62) | GRM4KCNH2HTR2BMTNR1AMAPT | |
| SCHEMBL18805529 | 0.78 | GRM4 (0.62) | GRM4KCNH2HTR2BMTNR1AMAPT | |
| SCHEMBL5318173 | 0.78 | GRM4 (0.62) | GRM4KCNH2HTR2BMTNR1AMAPT | |
| SCHEMBL355762 | 0.75 | GRM4 (0.65) | GRM4KCNH2HTR2BMTNR1A | |
| SCHEMBL31428975 | 0.75 | GRM4 (0.65) | GRM4KCNH2HTR2BMTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1264377-A | Substituted pyrazoles as P38 kinase inhabitors | SEARLE & CO (US) | 2000-08-23 | — | — | CN | claimed |
| EP-1000055-A1 | SUBSTITUTED PYRAZOLES AS p38 KINASE INHIBITORS | G.D. Searle & Co. (US) | 2000-05-17 | — | — | EP | claimed |
| WO-1998052940-A1 | SUBSTITUTED PYRAZOLES AS p38 KINASE INHIBITORS | G.D. SEARLE AND CO. (US) | 1998-11-26 | — | — | WO | claimed |
| CN-1342157-A | Substituted pyrazoles ASP38 kinase inhibitors | SEARLE & CO (US) | 2002-03-27 | — | — | CN | disclosed |
| EP-1144403-A1 | SUBSTITUED PYRAZOLES AS P38 KINASE INHIBITORS | G.D. SEARLE & CO. (US) | 2001-10-17 | — | — | EP | disclosed |
| CN-1273603-A | Attenuated respiratory syncytial virus | AMERICAN CYANAMID CO (US) | 2000-11-15 | — | — | CN | disclosed |
| WO-2000031063-A1 | SUBSTITUTED PYRAZOLES AS p38 KINASE INHIBITORS | G.D. SEARLE & CO. (US) | 2000-06-02 | — | — | WO | disclosed |