Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR1 | P25024 | 4/20 | 0.55 |
| ▸ | CXCR2 | P25025 | 4/20 | 0.55 |
| ▸ | MEN1 | O00255 | 6/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | KCNMA1 | Q12791 | 2/20 | 0.47 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | HTR1E | P28566 | 1/20 | 0.40 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7859409 | 0.85 | CXCR1 (0.52) | CXCR1CXCR2MEN1KMT2ATDP1 | |
| SCHEMBL7864067 | 0.83 | CXCR1 (0.52) | CXCR1CXCR2MEN1KMT2ATDP1 | |
| SCHEMBL7864070 | 0.83 | CXCR1 (0.52) | CXCR1CXCR2MEN1KMT2ATDP1 | |
| SCHEMBL7860578 | 0.83 | CXCR2 (0.51) | CXCR1CXCR2MEN1KMT2ATDP1 | |
| SCHEMBL7860580 | 0.83 | CXCR2 (0.51) | CXCR1CXCR2MEN1KMT2ATDP1 | |
| SCHEMBL7860582 | 0.83 | CXCR2 (0.51) | CXCR1CXCR2MEN1KMT2ATDP1 | |
| SCHEMBL7860753 | 0.79 | CXCR1 (0.54) | CXCR1CXCR2MEN1KMT2ATDP1 | |
| SCHEMBL7860750 | 0.79 | CXCR1 (0.54) | CXCR1CXCR2MEN1KMT2ATDP1 | |
| SCHEMBL7860746 | 0.79 | CXCR1 (0.54) | CXCR1CXCR2MEN1KMT2ATDP1 | |
| Urea SCHEMBL7864346 | 0.76 | CXCR1 (0.51) | CXCR1CXCR2MEN1KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0912505-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2001-10-24 | — | — | EP | disclosed |
| US-6133319-A | IL-8 receptor antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 2000-10-17 | — | — | US | disclosed |
| EP-0912505-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-05-06 | — | — | EP | disclosed |
| WO-1997049680-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-12-31 | — | — | WO | disclosed |