Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR1 | P25024 | 3/20 | 0.52 |
| ▸ | CXCR2 | P25025 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.42 |
| ▸ | PPIA | P62937 | 1/20 | 0.42 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | AXL | P30530 | 1/20 | 0.41 |
| ▸ | MERTK | Q12866 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | CTSV | O60911 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7864067 | 0.98 | CXCR1 (0.52) | CXCR1CXCR2MEN1KMT2ATDP1 | |
| SCHEMBL7864070 | 0.98 | CXCR1 (0.52) | CXCR1CXCR2MEN1KMT2ATDP1 | |
| SCHEMBL7859413 | 0.85 | CXCR1 (0.55) | CXCR1CXCR2MEN1KMT2ATDP1 | |
| SCHEMBL7861781 | 0.81 | CYP19A1 (0.47) | MEN1KMT2AKCNMA1MAPK1CYP19A1 | |
| SCHEMBL8204299 | 0.81 | CYP19A1 (0.47) | MEN1KMT2AKCNMA1MAPK1CYP19A1 | |
| SCHEMBL7860578 | 0.81 | CXCR2 (0.51) | CXCR1CXCR2MEN1KMT2ATDP1 | |
| SCHEMBL7860580 | 0.81 | CXCR2 (0.51) | CXCR1CXCR2MEN1KMT2ATDP1 | |
| SCHEMBL7860582 | 0.81 | CXCR2 (0.51) | CXCR1CXCR2MEN1KMT2ATDP1 | |
| SCHEMBL3103839 | 0.77 | NPC1 (0.56) | MEN1KMT2AMAPTGAAAXL | |
| SCHEMBL13156495 | 0.77 | NPC1 (0.56) | MEN1KMT2AMAPTGAAAXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0912505-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2001-10-24 | — | — | EP | disclosed |
| US-6133319-A | IL-8 receptor antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 2000-10-17 | — | — | US | disclosed |
| EP-0912505-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-05-06 | — | — | EP | disclosed |
| WO-1997049680-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-12-31 | — | — | WO | disclosed |