Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 6/20 | 0.51 |
| ▸ | HTR2C | P28335 | 4/20 | 0.48 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.48 |
| ▸ | HTR6 | P50406 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 4/20 | 0.46 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.46 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | NMT2 | O60551 | 1/20 | 0.41 |
| ▸ | NMT1 | P30419 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL8818387 | 0.84 | APP (0.54) | APPHTR1ASLC6A4 | |
| SCHEMBL5374013 | 0.84 | APP (0.58) | APPHTR1ASLC6A4 | |
| SCHEMBL22491588 | 0.79 | APP (0.54) | APPHTR2CADRB2HTR6NMT2 | |
| SCHEMBL19702109 | 0.76 | HTR2C (0.51) | HTR2CHTR6HTR1ASLC6A2SLC6A4 | |
| SCHEMBL8317118 | 0.75 | HTR2C (0.57) | APPHTR2CADRB2HTR6MTNR1A | |
| SCHEMBL2264043 | 0.75 | HTR2C (0.60) | APPHTR2CADRB2HTR6HTR1A | |
| SCHEMBL7866276 | 0.75 | HTR2C (0.44) | HTR2CHTR6HTR1ASLC6A2SLC6A4 | |
| Hydrochloric Acid SCHEMBL11841895 | 0.74 | HTR2C (0.58) | APPHTR2CADRB2HTR6HTR2B | |
| Hydrochloric Acid SCHEMBL11847902 | 0.74 | HTR2C (0.59) | APPHTR2CADRB2HTR6HTR1A | |
| SCHEMBL2781509 | 0.73 | HTR2C (0.62) | APPHTR2CADRB2HTR6HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077213-A2 | Inhibition of serotonin reuptake | ELI LILLY AND COMPANY (US) | 2001-02-21 | — | — | EP | disclosed |
| US-6046215-A | A PIPERIDINYLBENZOTHIOPHENES USEFUL FOR TRATING BRAIN DISORDERS | ELI LILLY AND COMPANY (US) | 2000-04-04 | — | — | US | disclosed |
| US-5846982-A | Inhibition of serotonin reuptake | ELI LILLY AND COMPANY (US) | 1998-12-08 | — | — | US | disclosed |
| EP-0812826-A1 | 1H-indole and benzo(b)thiophene derivatives with 4-(1,2,3,6-tetra:hydro:pyridinyl)- and 4-piperidinyl-groups bound to the heterocyclic ring as inhibitors of serotonin reuptake | ELI LILLY AND COMPANY (US) | 1997-12-17 | — | — | EP | disclosed |