Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 19/20 | 0.69 |
| ▸ | ESR2 | Q92731 | 12/20 | 0.69 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.48 |
| ▸ | TUBB | P07437 | 1/20 | 0.48 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.48 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.48 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.48 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.48 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.48 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.48 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.48 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.48 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.48 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.48 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.48 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.48 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7852990 | 0.94 | ESR1 (0.67) | ESR1ESR2 | |
| Arzoxifene SCHEMBL285277 | 0.81 | ESR1 (1.00) | ESR1ESR2 | |
| Arzoxifene SCHEMBL29354336 | 0.81 | ESR1 (1.00) | ESR1ESR2 | |
| Arzoxifene SCHEMBL29351083 | 0.81 | ESR1 (0.98) | ESR1ESR2 | |
| Arzoxifene SCHEMBL699600 | 0.81 | ESR1 (0.98) | ESR1ESR2 | |
| Arzoxifene SCHEMBL5970803 | 0.81 | ESR1 (0.98) | ESR1ESR2 | |
| Arzoxifene SCHEMBL5493113 | 0.80 | ESR1 (0.96) | ESR1ESR2 | |
| Arzoxifene SCHEMBL1649149 | 0.80 | ESR1 (0.96) | ESR1ESR2 | |
| SCHEMBL14613446 | 0.80 | ESR1 (0.76) | ESR1ESR2TUBB4ATUBBTUBA3C | |
| SCHEMBL7859976 | 0.80 | F2 (0.61) | ESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0791591-B1 | Benzothiophenes, formulations containing same, and methods for their préparation | LILLY CO ELI (US) | 2001-08-29 | — | — | EP | claimed |
| US-6258826-B1 | HALOGEN SUBSTITUTED BENZOTHIOPHENE COMPOUNDS WITH CARRIERS | ELI LILLY AND COMPANY | 2001-07-10 | — | — | US | claimed |
| EP-0791591-A1 | Benzothiophenes, formulations containing same, and methods | ELI LILLY AND COMPANY (US) | 1997-08-27 | — | — | EP | claimed |
| EP-0791591-B1 | Benzothiophenes, formulations containing same, and methods for their préparation | LILLY CO ELI (US) | 2001-08-29 | — | — | EP | disclosed |
| US-6258826-B1 | HALOGEN SUBSTITUTED BENZOTHIOPHENE COMPOUNDS WITH CARRIERS | ELI LILLY AND COMPANY | 2001-07-10 | — | — | US | disclosed |
| WO-1997030709-A1 | BENZOTHIOPHENES, FORMULATIONS CONTAINING SAME, AND METHODS | ELI LILLY AND COMPANY (US) | 1997-08-28 | — | — | WO | disclosed |
| EP-0791591-A1 | Benzothiophenes, formulations containing same, and methods | ELI LILLY AND COMPANY (US) | 1997-08-27 | — | — | EP | disclosed |