Trelnarizine

Trelnarizine

SCHEMBL7860094

COc1ccc(/C=C/CN2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1OC

nearest known ligand 0.64

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 6/20 0.64
DRD2 P14416 5/20 0.64
DRD3 P35462 5/20 0.64
OPRM1 P35372 4/20 0.64
HIF1A Q16665 4/20 0.64
MEN1 O00255 3/20 0.64
KMT2A Q03164 3/20 0.64
CYP2D6 P10635 3/20 0.64
CHRM2 P08172 3/20 0.64
ADORA3 P0DMS8 3/20 0.64
CHRM1 P11229 3/20 0.64
ADRA2B P18089 3/20 0.64
ADRA2C P18825 3/20 0.64
SLC6A2 P23975 3/20 0.64
HTR2A P28223 3/20 0.64
ADRA1A P35348 3/20 0.64
HRH1 P35367 3/20 0.64
HTR2B P41595 3/20 0.64
SLC6A3 Q01959 3/20 0.64
KCNH2 Q12809 3/20 0.64

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Trelnarizine SCHEMBL29388163 1.00 LMNA (0.64) LMNADRD2DRD3OPRM1HIF1A
Trelnarizine SCHEMBL7860095 1.00 LMNA (0.64) LMNADRD2DRD3OPRM1HIF1A
Trelnarizine SCHEMBL10803107 0.99 LMNA (0.65) LMNADRD2DRD3OPRM1HIF1A
Trelnarizine SCHEMBL10803100 0.99 LMNA (0.65) LMNADRD2DRD3OPRM1HIF1A
SCHEMBL24224625 0.85 LMNA (0.72) LMNADRD2DRD3OPRM1HIF1A
SCHEMBL9813081 0.83 LMNA (0.57) LMNADRD2DRD3OPRM1HIF1A
SCHEMBL1152474 0.81 LMNA (0.64) LMNADRD2DRD3OPRM1HIF1A
SCHEMBL1152476 0.81 LMNA (0.64) LMNADRD2DRD3OPRM1HIF1A
SCHEMBL1152486 0.81 LMNA (0.56) LMNADRD2DRD3OPRM1HIF1A
Hydrochloric Acid SCHEMBL9809256 0.81 LMNA (0.63) LMNADRD2DRD3OPRM1HIF1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0152799-B1 COMPOUNDS HAVING PERIPHERAL CALCIUM ANTAGONIST, ANTICONVULSIVE AND EUMETABOLIC ACTIVITY, PROCESSES FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM PULITZER ITALIANA S.p.A. (IT) 1987-10-28 EP claimed
EP-0152799-A1 Compounds having peripheral calcium antagonist, anticonvulsive and eumetabolic activity, processes for the preparation thereof and pharmaceutical compositions containing them PULITZER ITALIANA S.p.A. (IT) 1985-08-28 EP claimed
WO-2024135056-A1 SOLID-STATE IMAGING DEVICE, METHOD FOR MANUFACTURING SOLID-STATE IMAGING DEVICE, AND ELECTRONIC APPARATUS ゼタテクノロジーズ株式会社 2024-06-27 WO disclosed
WO-2024135058-A1 SOLID-STATE IMAGING APPARATUS, METHOD FOR MANUFACTURING SOLID-STATE IMAGING APPARATUS, AND ELECTRONIC DEVICE ゼタテクノロジーズ株式会社 2024-06-27 WO disclosed
WO-2024135057-A1 SOLID-STATE IMAGING DEVICE, METHOD FOR MANUFACTURING SOLID-STATE IMAGING DEVICE, AND ELECTRONIC APPARATUS ゼタテクノロジーズ株式会社 2024-06-27 WO disclosed
CN-114679551-B Solid-state imaging device, signal processing method for solid-state imaging device, and electronic apparatus 广东京之映科技有限公司 2024-01-02 CN disclosed
WO-2023248693-A1 SOLID-STATE IMAGING DEVICE, METHOD FOR MANUFACTURING SOLID-STATE IMAGING DEVICE, AND ELECTRONIC APPARATUS ゼタテクノロジーズ株式会社 2023-12-28 WO disclosed
CN-115550574-A Solid-state imaging device, method for manufacturing solid-state imaging device, and electronic apparatus 广东京之映科技有限公司 2022-12-30 CN disclosed
US-20220415939-A1 SOLID-STATE IMAGING APPARATUS, METHOD FOR MANUFACTURING THE SAME, AND ELECTRONIC DEVICE SUPERBVUE SOLUTIONS INC. (CN) 2022-12-29 US disclosed
CN-114679551-A Solid-state imaging device, signal processing method for solid-state imaging device, and electronic apparatus 广东京之映科技有限公司 2022-06-28 CN disclosed
EP-0682664-B1 COMPOUNDS HAVING BOTH POTENT CALCIUM ANTAGONIST AND ANTIOXIDANT ACTIVITY AND USE THEREOF AS CYTOPROTECTIVE AGENTS ALCON LAB INC (US) 2001-03-14 EP disclosed
EP-0187639-B1 NOVEL PIPERAZINE DERIVATIVES, PROCESSES FOR PRODUCTION THEREOF, AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAID COMPOUNDS AS ACTIVE INGREDIENT KANEBO, LTD. (JP) 1991-05-02 EP disclosed
EP-0152799-B1 COMPOUNDS HAVING PERIPHERAL CALCIUM ANTAGONIST, ANTICONVULSIVE AND EUMETABOLIC ACTIVITY, PROCESSES FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM PULITZER ITALIANA S.p.A. (IT) 1987-10-28 EP disclosed
US-4703048-A Novel 1-benzhydryl-4-cinnamylpiperazine derivatives, and pharmaceutical compositions comprising said compounds as active ingredient for treating a cerebrovascular disease KANEBO LTD. (JP) 1987-10-27 US disclosed
EP-0152799-A1 Compounds having peripheral calcium antagonist, anticonvulsive and eumetabolic activity, processes for the preparation thereof and pharmaceutical compositions containing them PULITZER ITALIANA S.p.A. (IT) 1985-08-28 EP disclosed