Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 4/20 | 0.43 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | SSTR5 | P35346 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7860295 | 1.00 | KCNH2 (0.43) | KCNH2NR4A2ALDH1A1TAAR1SSTR5 | |
| SCHEMBL7854950 | 0.84 | KDM4E (0.45) | KCNH2NR4A2KMT2A | |
| SCHEMBL7854951 | 0.84 | KDM4E (0.45) | KCNH2NR4A2KMT2A | |
| SCHEMBL7861589 | 0.82 | KCNH2 (0.70) | KCNH2NR4A2ALDH1A1SSTR5LMNA | |
| SCHEMBL7861587 | 0.82 | KCNH2 (0.70) | KCNH2NR4A2ALDH1A1SSTR5LMNA | |
| SCHEMBL7865204 | 0.81 | KCNH2 (0.48) | KCNH2NR4A2ALDH1A1SSTR5LMNA | |
| SCHEMBL7862726 | 0.81 | KCNH2 (0.46) | KCNH2NR4A2SSTR5LMNAKMT2A | |
| SCHEMBL7865206 | 0.81 | KCNH2 (0.48) | KCNH2NR4A2ALDH1A1SSTR5LMNA | |
| Oxalic Acid SCHEMBL7864912 | 0.81 | HRH1 (0.45) | KCNH2NR4A2ALDH1A1 | |
| Oxalic Acid SCHEMBL7864914 | 0.81 | HRH1 (0.45) | KCNH2NR4A2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0869955-B1 | N-ACYL-2-SUBSTITUTED-4-(BENZIMIDAZOLYL- OR IMIDAZOPYRIDINYL-SUBSTITUTED RESIDUES)-PIPERIDINES AS TACHYKININ ANTAGONISTS | JANSSEN PHARMACEUTICA NV (BE) | 2001-10-24 | — | — | EP | disclosed |