Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 8/20 | 0.45 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | GPR142 | Q7Z601 | 4/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2727189 | 0.80 | PIK3CA (0.51) | PIK3CACREBBP | |
| SCHEMBL7878242 | 0.79 | PIK3CA (0.48) | PIK3CALMNAHPGDSMN1; SMN2POLB | |
| SCHEMBL13173994 | 0.78 | PIK3CA (0.48) | PIK3CALMNAHPGDSMN1; SMN2POLB | |
| SCHEMBL15603621 | 0.77 | LMNA (0.45) | PIK3CALMNAHPGDSMN1; SMN2POLB | |
| SCHEMBL13174050 | 0.77 | PIK3CA (0.46) | PIK3CALMNAHPGDSMN1; SMN2POLB | |
| SCHEMBL3792121 | 0.77 | PIK3CA (0.68) | PIK3CA | |
| SCHEMBL13173983 | 0.76 | PIK3CA (0.48) | PIK3CALMNAHPGDSMN1; SMN2POLB | |
| SCHEMBL7877195 | 0.76 | PIK3CA (0.48) | PIK3CALMNAHPGDSMN1; SMN2POLB | |
| SCHEMBL13173995 | 0.76 | PIK3CA (0.46) | PIK3CALMNAHPGDSMN1; SMN2POLB | |
| SCHEMBL7877202 | 0.76 | PIK3CA (0.51) | PIK3CALMNAHPGDSMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010135524-A1 | BENZOXAZEPINES BASED P13K/MT0R INHIBITORS AGAINST PROLIFERATIVE DISEASES | EXELIXIS, INC. (US) | 2010-11-25 | — | — | WO | disclosed |