Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | PLOD2 | O00469 | 3/20 | 0.55 |
| ▸ | PLOD3 | O60568 | 2/20 | 0.55 |
| ▸ | PLOD1 | Q02809 | 2/20 | 0.55 |
| ▸ | PDE4A | P27815 | 2/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.45 |
| ▸ | NISCH | Q9Y2I1 | 2/20 | 0.44 |
| ▸ | FASN | P49327 | 1/20 | 0.43 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
| ▸ | ADK | P55263 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | F10 | P00742 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7024684 | 0.78 | KDM4E (0.66) | KDM4EALDH1A1PDE4APDE4BPDE4C | |
| SCHEMBL7020447 | 0.76 | KDM4E (0.62) | KDM4EALDH1A1PDE4APDE4BPDE4C | |
| SCHEMBL17303458 | 0.75 | KDM4E (0.77) | KDM4EALDH1A1PDE4APDE4BPDE4C | |
| SCHEMBL28604462 | 0.75 | KDM4E (0.66) | KDM4EALDH1A1PDE4APDE4BPDE4C | |
| SCHEMBL1060312 | 0.74 | KDM4E (1.00) | KDM4EALDH1A1PDE4APDE4BPDE4C | |
| SCHEMBL29140743 | 0.73 | KDM4E (1.00) | KDM4EALDH1A1PDE4APDE4BPDE4C | |
| SCHEMBL6666160 | 0.72 | PLOD2 (0.66) | KDM4EALDH1A1PLOD2PLOD3PLOD1 | |
| SCHEMBL7383120 | 0.72 | KDM4E (0.72) | KDM4EALDH1A1PDE4APDE4BPDE4C | |
| SCHEMBL5941063 | 0.72 | KDM4E (0.72) | KDM4EALDH1A1PDE4APDE4BPDE4C | |
| SCHEMBL3634334 | 0.72 | KDM4E (0.72) | KDM4EALDH1A1PDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1086097-A1 | SULFONYLBENZENE COMPOUNDS AS ANTI-INFLAMMATORY/ANALGESIC AGENTS | PFIZER INC. (US) | 2001-03-28 | — | — | EP | disclosed |
| WO-1999064415-A1 | SULFONYLBENZENE COMPOUNDS AS ANTI-INFLAMMATORY/ANALGESIC AGENTS | PFIZER PHARMACEUTICALS INC. (JP) | 1999-12-16 | — | — | WO | disclosed |