Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 10/20 | 0.53 |
| ▸ | DHODH | Q02127 | 3/20 | 0.44 |
| ▸ | VSIR | Q9H7M9 | 3/20 | 0.43 |
| ▸ | MMP2 | P08253 | 2/20 | 0.43 |
| ▸ | MMP9 | P14780 | 2/20 | 0.43 |
| ▸ | MMP8 | P22894 | 2/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.43 |
| ▸ | MARK3 | P27448 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | CLK2 | P49760 | 1/20 | 0.43 |
| ▸ | GSK3A | P49840 | 1/20 | 0.43 |
| ▸ | ITK | Q08881 | 1/20 | 0.43 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6379926 | 0.91 | PARP1 (0.58) | PARP1VSIRCHEK1MAP4K4LCK | |
| SCHEMBL7859132 | 0.89 | PARP1 (0.52) | PARP1DHODHCHEK1MAP4K4LCK | |
| SCHEMBL7138597 | 0.81 | PARP1 (0.80) | PARP1DHODHCHEK1MAP4K4LCK | |
| SCHEMBL6383270 | 0.81 | PARP1 (0.51) | PARP1VSIRCHEK1MAP4K4LCK | |
| SCHEMBL6380476 | 0.80 | PARP1 (0.72) | PARP1VSIRMAP4K4PIM1PIM3 | |
| SCHEMBL6379799 | 0.80 | PARP1 (0.56) | PARP1DHODHCHEK1MAP4K4LCK | |
| SCHEMBL7853256 | 0.78 | PARP1 (0.65) | PARP1DHODHHPSE | |
| SCHEMBL7860364 | 0.78 | PARP1 (0.69) | PARP1DHODHKDRAURKB | |
| SCHEMBL6383675 | 0.75 | PARP1 (0.57) | PARP1DHODHVSIRPIM1PIM3 | |
| SCHEMBL6381528 | 0.74 | PARP1 (0.58) | PARP1VSIRMAP4K4PIM1PIM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1131301-A1 | 2-PHENYLBENZIMIDAZOLES AND 2-PHENYLINDOLES, AND PRODUCTION AND USE THEREOF | BASF AKTIENGESELLSCHAFT (DE) | 2001-09-12 | — | — | EP | disclosed |
| WO-2000029384-A1 | 2-PHENYLBENZIMIDAZOLES AND 2-PHENYLINDOLES, AND PRODUCTION AND USE THEREOF | BASF AKTIENGESELLSCHAFT (DE) | 2000-05-25 | — | — | WO | disclosed |