Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 4/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13558420 | 1.00 | CYP3A4 (0.46) | CYP3A4CYP2C9CYP2C19MAOBPOLB | |
| Nyasol SCHEMBL8416158 | 0.92 | APP (0.43) | CYP3A4CYP2C9CYP2C19MAOBPOLB | |
| Nyasol SCHEMBL30712027 | 0.92 | APP (0.43) | CYP3A4CYP2C9CYP2C19MAOBPOLB | |
| Nyasol SCHEMBL776219 | 0.92 | APP (0.43) | CYP3A4CYP2C9CYP2C19MAOBPOLB | |
| Nyasol SCHEMBL799383 | 0.92 | APP (0.43) | CYP3A4CYP2C9CYP2C19MAOBPOLB | |
| Nyasol SCHEMBL776218 | 0.92 | APP (0.43) | CYP3A4CYP2C9CYP2C19MAOBPOLB | |
| SCHEMBL7864584 | 0.83 | MAPT (0.50) | CYP3A4CYP2C9CYP2C19MAPTRAB9A | |
| SCHEMBL7861615 | 0.83 | MAPT (0.50) | CYP3A4CYP2C9CYP2C19MAPTRAB9A | |
| SCHEMBL805124 | 0.83 | MAPT (0.50) | CYP3A4CYP2C9CYP2C19MAPTRAB9A | |
| SCHEMBL799612 | 0.83 | MAOB (0.39) | CYP3A4CYP2C9CYP2C19MAOBPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120277169-A1 | NYASOL AND ANALOGS THEREOF FOR THE TREATMENT OF ESTROGEN RECEPTOR BETA-MEDIATED DISEASES | BIONOVO, INC. (US) | 2012-11-01 | — | — | US | disclosed |
| US-20090312274-A1 | Nyasol and Analogs Thereof for the Treatment of Estrogen Receptor Beta-Mediated Diseases | BIONOVO, INC. (US) | 2009-12-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090312274-A1 | Nyasol and Analogs Thereof for the Treatment of Estrogen Receptor Beta-Mediated Diseases | ESR2, ESR1, ESRRA | CYP3A4 3838/4885CYP2C9 4584/4885CYP2C19 3750/4885 |
| US-20120277169-A1 | NYASOL AND ANALOGS THEREOF FOR THE TREATMENT OF ESTROGEN RECEPTOR BETA-MEDIATED DISEASES | ESR2, ESR1, ESRRA | CYP3A4 3838/4885CYP2C9 4584/4885CYP2C19 3750/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.