Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR1 | P25024 | 1/20 | 0.41 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.39 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10987754 | 0.78 | ALDH1A1 (0.39) | ALDH1A1KDM4EGAAMEN1MAPT | |
| SCHEMBL6363096 | 0.78 | ALDH1A1 (0.35) | ALDH1A1KDM4EGAAMEN1MAPT | |
| SCHEMBL10984237 | 0.75 | ALDH1A1 (0.43) | ALDH1A1KDM4EMEN1MAPTKMT2A | |
| SCHEMBL5595008 | 0.75 | ALDH1A1 (0.39) | ALDH1A1KDM4EGAAMEN1MAPT | |
| SCHEMBL3561080 | 0.74 | PRKACA (0.42) | ALDH1A1KDM4EGAAMEN1MAPT | |
| SCHEMBL4334905 | 0.74 | ALDH1A1 (0.45) | CXCR1CXCR2ALDH1A1KDM4EGAA | |
| SCHEMBL11789185 | 0.73 | ALDH1A1 (0.37) | ALDH1A1KDM4EGAAMEN1MAPT | |
| SCHEMBL29927582 | 0.72 | CA1 (0.48) | ALDH1A1GAACA12CA1CA2 | |
| SCHEMBL26096976 | 0.72 | CA1 (0.48) | ALDH1A1GAACA12CA1CA2 | |
| SCHEMBL9575176 | 0.71 | ALDH1A1 (0.43) | ALDH1A1KDM4EMEN1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0915651-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2001-10-24 | — | — | EP | disclosed |
| US-6271261-B1 | CHEMOKINE MEDIATED DISEASES, BINDING INTERLEUKINS OR BETA-RECEPTORS AND ADMINISTERING TO MAMMALS | SMITHKLINE BEECHAM CORPORATION | 2001-08-07 | — | — | US | disclosed |
| EP-0915651-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-05-19 | — | — | EP | disclosed |
| WO-1997049286-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-12-31 | — | — | WO | disclosed |