Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.49 |
| ▸ | TNF | P01375 | 3/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL664005 | 0.85 | HDAC6 (0.55) | HDAC6TNFHDAC3HDAC4HDAC1 | |
| SCHEMBL5562061 | 0.85 | HDAC6 (0.55) | HDAC6TNFHDAC3HDAC4HDAC1 | |
| SCHEMBL7848577 | 0.84 | HDAC6 (0.48) | HDAC6TNFHDAC3HDAC4HDAC1 | |
| SCHEMBL2922474 | 0.84 | TNF (0.54) | HDAC6TNFHDAC3HDAC4HDAC1 | |
| SCHEMBL4376874 | 0.83 | HDAC6 (0.53) | HDAC6TNFHDAC3HDAC4HDAC1 | |
| SCHEMBL7210734 | 0.83 | HDAC6 (0.53) | HDAC6TNFHDAC3HDAC4HDAC1 | |
| SCHEMBL4381827 | 0.81 | HDAC6 (0.51) | HDAC6TNFHDAC3HDAC4HDAC1 | |
| SCHEMBL4378142 | 0.81 | HDAC6 (0.48) | HDAC6TNFHDAC3HDAC4HDAC1 | |
| SCHEMBL7205402 | 0.81 | HDAC6 (0.51) | HDAC6TNF | |
| SCHEMBL7452615 | 0.81 | HDAC6 (0.50) | HDAC6TNFHDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0873319-B1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2001-07-25 | — | — | EP | disclosed |