Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7869148 | 0.78 | TSHR (0.32) | TSHR | |
| SCHEMBL465382 | 0.75 | TSHR (0.39) | TSHR | |
| SCHEMBL465304 | 0.75 | TSHR (0.39) | TSHR | |
| SCHEMBL28399026 | 0.73 | TSHR (0.37) | TSHR | |
| SCHEMBL465474 | 0.71 | TSHR (0.35) | TSHR | |
| SCHEMBL2363878 | 0.70 | TSHR (0.30) | TSHR | |
| SCHEMBL1641574 | 0.69 | — | — | |
| SCHEMBL9950758 | 0.69 | TSHR (0.33) | TSHR | |
| SCHEMBL5056952 | 0.69 | TSHR (0.40) | TSHR | |
| SCHEMBL11173115 | 0.69 | MAPT (0.36) | TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0418099-B1 | Process of preparation of 10, 11-Methylenedioxy-20 (RS) camptothecin and 10, 11-methylenedioxy-20 (S) - camptothecin analog | RES TRIANGLE INST (US) | 2001-12-19 | — | — | EP | disclosed |
| US-5340817-A | Method of treating tumors with anti-tumor effective camptothecin compounds | RESEARCH TRIANGLE INSTITUTE (US) | 1994-08-23 | — | — | US | disclosed |
| US-5180722-A | Topisomerase Inhibitors, Anticarcinogenic Agents | RESEARCH TRIANGLE INSTITUTE (US) | 1993-01-19 | — | — | US | disclosed |
| WO-1991004260-A2 | 10,11-METHYLENEDIOXY-20(RS)-CAMPTOTHECIN AND 10,11-METHYLENEDIOXY-20(S)-CAMPTOTHECIN ANALOGS | RESEARCH TRIANGLE INSTITUTE (US) | 1991-04-04 | — | — | WO | disclosed |
| EP-0418099-A2 | 10, 11-Methylenedioxy-20 (RS) camptothecin and 10, 11-methylenedioxy-20 (S) - camptothecin analog | RESEARCH TRIANGLE INSTITUTE (US) | 1991-03-20 | — | — | EP | disclosed |