Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 16/20 | 0.65 |
| ▸ | PRKCA | P17252 | 3/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5870061 | 0.93 | TOP1 (0.58) | TOP1DYRK1APAX8 | |
| SCHEMBL5870062 | 0.89 | TOP1 (0.54) | TOP1 | |
| SCHEMBL6724824 | 0.88 | TOP1 (0.61) | TOP1PRKCADYRK1APAX8EGFR | |
| SCHEMBL5870514 | 0.88 | TOP1 (0.61) | TOP1PRKCADYRK1APAX8EGFR | |
| SCHEMBL7860461 | 0.88 | TOP1 (0.54) | TOP1 | |
| SCHEMBL5869927 | 0.87 | TOP1 (0.55) | TOP1PRKCA | |
| SCHEMBL6736290 | 0.87 | TOP1 (0.57) | TOP1PRKCA | |
| SCHEMBL8192076 | 0.87 | TOP1 (0.52) | TOP1 | |
| SCHEMBL6731712 | 0.85 | TOP1 (0.47) | TOP1PRKCA | |
| SCHEMBL7031130 | 0.85 | TOP1 (0.54) | TOP1PRKCADYRK1APAX8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0971717-B1 | CYTOTOXIC AMINO SUGAR AND RELATED SUGAR DERIVATIVES OF INDOLOPYRROLOCARBAZOLES | BRISTOL MYERS SQUIBB CO (US) | 2001-12-19 | — | — | EP | disclosed |
| EP-0971717-A4 | CYTOTOXIC AMINO SUGAR AND RELATED SUGAR DERIVATIVES OF INDOLOPYRROLOCARBAZOLES | BRISTOL MYERS SQUIBB CO (US) | 2000-04-12 | — | — | EP | disclosed |
| EP-0971717-A1 | CYTOTOXIC AMINO SUGAR AND RELATED SUGAR DERIVATIVES OF INDOLOPYRROLOCARBAZOLES | Bristol-Myers Squibb Company (US) | 2000-01-19 | — | — | EP | disclosed |
| WO-1998007433-A1 | CYTOTOXIC AMINO SUGAR AND RELATED SUGAR DERIVATIVES OF INDOLOPYRROLOCARBAZOLES | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-02-26 | — | — | WO | disclosed |