Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 14/20 | 0.52 |
| ▸ | CCNE2 | O96020 | 3/20 | 0.38 |
| ▸ | CDK4 | P11802 | 3/20 | 0.38 |
| ▸ | CCND1 | P24385 | 3/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.38 |
| ▸ | CDK2 | P24941 | 3/20 | 0.38 |
| ▸ | PRKACA | P17612 | 1/20 | 0.38 |
| ▸ | PRKACG | P22612 | 1/20 | 0.38 |
| ▸ | PRKACB | P22694 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.36 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.36 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.36 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.36 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5870061 | 0.90 | TOP1 (0.58) | TOP1CCNE2CDK4CCND1CCNE1 | |
| SCHEMBL6724824 | 0.89 | TOP1 (0.61) | TOP1 | |
| SCHEMBL5870514 | 0.89 | TOP1 (0.61) | TOP1 | |
| SCHEMBL7861913 | 0.87 | TOP1 (0.65) | TOP1 | |
| SCHEMBL7861934 | 0.83 | TOP1 (0.42) | TOP1HTR1ABCHE | |
| SCHEMBL7024637 | 0.83 | TOP1 (0.51) | TOP1CCNE2CDK4CCND1CCNE1 | |
| SCHEMBL7860461 | 0.83 | TOP1 (0.54) | TOP1CCNE2CDK4CCND1CCNE1 | |
| SCHEMBL5870062 | 0.82 | TOP1 (0.54) | TOP1CCNE2CDK4CCND1CCNE1 | |
| SCHEMBL5870241 | 0.80 | TOP1 (0.51) | TOP1CCNE2CDK4CCND1CCNE1 | |
| SCHEMBL6731989 | 0.79 | TOP1 (0.62) | TOP1CCNE2CDK4CCND1CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0971717-A4 | CYTOTOXIC AMINO SUGAR AND RELATED SUGAR DERIVATIVES OF INDOLOPYRROLOCARBAZOLES | BRISTOL MYERS SQUIBB CO (US) | 2000-04-12 | — | — | EP | disclosed |
| EP-0971717-A1 | CYTOTOXIC AMINO SUGAR AND RELATED SUGAR DERIVATIVES OF INDOLOPYRROLOCARBAZOLES | Bristol-Myers Squibb Company (US) | 2000-01-19 | — | — | EP | disclosed |
| WO-1998007433-A1 | CYTOTOXIC AMINO SUGAR AND RELATED SUGAR DERIVATIVES OF INDOLOPYRROLOCARBAZOLES | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-02-26 | — | — | WO | disclosed |