Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 4/20 | 0.76 |
| ▸ | ITGA2B | P08514 | 4/20 | 0.76 |
| ▸ | ITGAV | P06756 | 2/20 | 0.55 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.55 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.55 |
| ▸ | NR1H4 | Q96RI1 | 6/20 | 0.52 |
| ▸ | PPARD | Q03181 | 3/20 | 0.52 |
| ▸ | PPARG | P37231 | 2/20 | 0.52 |
| ▸ | PPARA | Q07869 | 2/20 | 0.52 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | HSPH1 | Q92598 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.47 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7373419 | 0.91 | ITGB3 (0.66) | ITGB3ITGA2BITGAVITGB1ITGB5 | |
| SCHEMBL7457414 | 0.90 | ITGB3 (0.84) | ITGB3ITGA2BITGAVITGB1ITGB5 | |
| SCHEMBL7346500 | 0.89 | ITGB3 (0.60) | ITGB3ITGA2BITGAVITGB1ITGB5 | |
| SCHEMBL8371218 | 0.89 | ITGB3 (0.61) | ITGB3ITGA2BITGAVITGB1ITGB5 | |
| SCHEMBL8500653 | 0.88 | ITGB3 (0.60) | ITGB3ITGA2BITGAVITGB1ITGB5 | |
| SCHEMBL7856521 | 0.88 | PPARG (0.60) | ITGB3ITGA2BITGAVITGB1ITGB5 | |
| SCHEMBL7864209 | 0.87 | HPSE (0.62) | ITGB3ITGA2BNR1H4PPARDPPARG | |
| SCHEMBL7378120 | 0.86 | ITGB3 (0.57) | ITGB3ITGA2BITGAVITGB1ITGB5 | |
| SCHEMBL7856482 | 0.86 | ITGB3 (0.65) | ITGB3ITGA2BITGB1NR1H4PPARD | |
| SCHEMBL7380122 | 0.85 | ITGB3 (0.56) | ITGB3ITGA2BITGAVITGB1ITGB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0889877-B1 | META-SUBSTITUTED PHENYLENE DERIVATIVES AND THEIR USE AS ALPHAvBETA3 INTEGRIN ANTAGONISTS OR INHIBITORS | SEARLE & CO (US) | 2001-08-29 | — | — | EP | claimed |
| EP-0889877-A1 | META-SUBSTITUTED PHENYLENE DERIVATIVES AND THEIR USE AS ALPHAvBETA3 INTEGRIN ANTAGONISTS OR INHIBITORS | G.D. SEARLE & CO. (US) | 1999-01-13 | — | — | EP | claimed |
| WO-1997036862-A1 | META-SUBSTITUTED PHENYLENE DERIVATIVES AND THEIR USE AS ALPHAvBETA3 INTEGRIN ANTAGONISTS OR INHIBITORS | G.D. SEARLE & CO. (US) | 1997-10-09 | — | — | WO | claimed |
| EP-0889877-B1 | META-SUBSTITUTED PHENYLENE DERIVATIVES AND THEIR USE AS ALPHAvBETA3 INTEGRIN ANTAGONISTS OR INHIBITORS | SEARLE & CO (US) | 2001-08-29 | — | — | EP | disclosed |
| EP-0889877-A1 | META-SUBSTITUTED PHENYLENE DERIVATIVES AND THEIR USE AS ALPHAvBETA3 INTEGRIN ANTAGONISTS OR INHIBITORS | G.D. SEARLE & CO. (US) | 1999-01-13 | — | — | EP | disclosed |
| WO-1997036862-A1 | META-SUBSTITUTED PHENYLENE DERIVATIVES AND THEIR USE AS ALPHAvBETA3 INTEGRIN ANTAGONISTS OR INHIBITORS | G.D. SEARLE & CO. (US) | 1997-10-09 | — | — | WO | disclosed |