SCHEMBL7862514

SCHEMBL7862514

C[SiH](C)OC[C@]1(C(C)(C)C)[C@@H](O)CCN1C(=O)OC(C)(C)C

nearest known ligand 0.35

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CHRM2 P08172 1/20 0.35
CHRM1 P11229 1/20 0.35
CHRM3 P20309 1/20 0.35
DDB1 Q16531 1/20 0.34
CRBN Q96SW2 1/20 0.34
HPGD P15428 1/20 0.33
RECQL P46063 1/20 0.32
EPHX1 P07099 1/20 0.32
CTSK P43235 1/20 0.31
USP2 O75604 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
MEN1 O00255 1/20 0.31
ALDH1A1 P00352 1/20 0.31
MAPT P10636 1/20 0.31
KMT2A Q03164 1/20 0.31
NR1H2 P55055 1/20 0.31
EPHX2 P34913 1/20 0.31
PREP P48147 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24069211 0.72 CHRM2 (0.44) CHRM2CHRM1CHRM3DDB1CRBN
SCHEMBL4698979 0.71 NR1H2 (0.36) CHRM2CHRM1CHRM3NR1H2EPHX2
SCHEMBL28735688 0.69 CHRM2 (0.41) CHRM2CHRM1CHRM3DDB1CRBN
SCHEMBL29519744 0.69 CHRM2 (0.41) CHRM2CHRM1CHRM3DDB1CRBN
SCHEMBL30832433 0.69 CHRM2 (0.41) CHRM2CHRM1CHRM3DDB1CRBN
SCHEMBL143165 0.69 CHRM2 (0.38) CHRM2CHRM1CHRM3DDB1CRBN
SCHEMBL144061 0.69 CHRM2 (0.38) CHRM2CHRM1CHRM3DDB1CRBN
SCHEMBL3166102 0.68 CHRM2 (0.40) CHRM2CHRM1CHRM3DDB1CRBN
SCHEMBL4370463 0.67 CHRM2 (0.39) CHRM2CHRM1CHRM3DDB1CRBN
SCHEMBL6026752 0.67 CHRM2 (0.39) CHRM2CHRM1CHRM3DDB1CRBN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6310095-B1 INHIBITING OR TREATING CANCER, TREATING INTIMAL HYPERPLASIA ASSOCIATED WITH RESTENOSIS AND ATHEROSCLEROSIS, INHIBITING POST-TRANSLATIONAL MODIFICATION OF ONCOGENIC RAS PROTEIN BY PROTEIN FARNESYLTRANSFERASE AND/OR GERANYLGERANYLTRANSFERASE UNIVERSITY OF PITTSBURGH 2001-10-30 US disclosed