Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | CTSL | P07711 | 3/20 | 0.51 |
| ▸ | CTSS | P25774 | 3/20 | 0.51 |
| ▸ | CTSB | P07858 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | CTSK | P43235 | 2/20 | 0.48 |
| ▸ | CASP3 | P42574 | 2/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | SYK | P43405 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA5A | P35218 | 1/20 | 0.42 |
| ▸ | MME | P08473 | 1/20 | 0.41 |
| ▸ | ECE1 | P42892 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7862070 | 0.91 | CA2 (0.48) | CYP3A4CYP2D6CYP2C9CYP2C19RAB9A | |
| SCHEMBL7860526 | 0.89 | CYP3A4 (0.57) | CYP3A4CYP2D6CYP2C9CYP2C19RAB9A | |
| SCHEMBL7862146 | 0.88 | CYP3A4 (0.52) | CYP3A4CYP2D6CYP2C9CYP2C19RAB9A | |
| SCHEMBL7862112 | 0.85 | SYK (0.46) | CYP3A4CYP2D6CYP2C9CYP2C19RAB9A | |
| SCHEMBL3735287 | 0.85 | CA2 (0.49) | CYP3A4CYP2D6CYP2C9CYP2C19RAB9A | |
| SCHEMBL3732278 | 0.83 | CYP3A4 (0.59) | CYP3A4CYP2D6CYP2C9CYP2C19RAB9A | |
| SCHEMBL5398876 | 0.81 | CYP3A4 (0.67) | CYP3A4CYP2D6CYP2C9CYP2C19RAB9A | |
| SCHEMBL5398872 | 0.81 | CYP3A4 (0.67) | CYP3A4CYP2D6CYP2C9CYP2C19RAB9A | |
| SCHEMBL7860507 | 0.80 | CA2 (0.52) | CTSLCTSSCTSBMEN1KMT2A | |
| SCHEMBL7860528 | 0.80 | MAPT (0.47) | CYP3A4CYP2D6CYP2C9CYP2C19RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1121366-A1 | PRODRUGS OF PHOSPHOROUS-CONTAINING PHARMACEUTICALS | MEDIVIR AB (SE) | 2001-08-08 | — | — | EP | disclosed |
| WO-1999051613-A1 | PRODRUGS OF PHOSPHOROUS-CONTAINING PHARMACEUTICALS | MEDIVIR AB (SE) | 1999-10-14 | — | — | WO | disclosed |