SCHEMBL7863113

SCHEMBL7863113

Cc1cccc(C(=O)OCc2ccccc2)c1-c1ccccc1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.58
TDP1 Q9NUW8 3/20 0.56
L3MBTL1 Q9Y468 5/20 0.54
TSHR P16473 3/20 0.54
CYP3A4 P08684 2/20 0.54
MAPK1 P28482 1/20 0.54
KMT2A Q03164 2/20 0.50
SLC6A2 P23975 1/20 0.50
SLC6A3 Q01959 1/20 0.50
RAB9A P51151 3/20 0.49
CASP3 P42574 1/20 0.49
SENP8 Q96LD8 1/20 0.49
SENP7 Q9BQF6 1/20 0.49
SENP6 Q9GZR1 1/20 0.49
POLB P06746 1/20 0.49
NPC1 O15118 2/20 0.48
FABP4 P15090 1/20 0.47
LMNA P02545 1/20 0.46
MEN1 O00255 1/20 0.45
PPARG P37231 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4741015 0.88 ALDH1A1 (0.49) ALDH1A1TDP1L3MBTL1TSHRCYP3A4
SCHEMBL27651181 0.85 ALDH1A1 (0.58) ALDH1A1TDP1L3MBTL1TSHRCYP3A4
SCHEMBL21264504 0.85 ALDH1A1 (0.48) ALDH1A1TDP1L3MBTL1TSHRCYP3A4
SCHEMBL2705753 0.84 ALDH1A1 (0.69) ALDH1A1TDP1L3MBTL1TSHRCYP3A4
SCHEMBL29353285 0.84 ALDH1A1 (0.69) ALDH1A1TDP1L3MBTL1TSHRCYP3A4
SCHEMBL27530304 0.84 ALDH1A1 (0.59) ALDH1A1TDP1L3MBTL1TSHRCYP3A4
SCHEMBL17971091 0.83 ALDH1A1 (0.63) ALDH1A1TDP1L3MBTL1TSHRCYP3A4
Hydrochloric Acid SCHEMBL27584631 0.83 ALDH1A1 (0.67) ALDH1A1TDP1L3MBTL1TSHRCYP3A4
SCHEMBL25564479 0.82 ALDH1A1 (0.51) ALDH1A1TDP1L3MBTL1TSHRCYP3A4
SCHEMBL5695975 0.82 TDP1 (0.64) ALDH1A1TDP1L3MBTL1TSHRCYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6303593-B1 FOR THERAPY HUMAN IMMUNODEFICIENCY VIRUS INFECTION, AQUIRED IMMUNODEFICIENCY SYNDROME (AIDS), INFLAMMATORY AND IMMUNOREGULATORY DISORDER OR DISEASE, ASTHMA, ALLERGIC RHINITIS, DERMATITIS, CONJUNCTIVITIS, ATHEROSCLEROSIS MERCK & CO., INC. 2001-10-16 US disclosed
WO-2000051608-A1 3-THIENYL AND 3-FURANYL PYRROLIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY MERCK & CO., INC. (US) 2000-09-08 WO disclosed