SCHEMBL7863545

SCHEMBL7863545

CCO/N=C(C(/C)=N/OCc1ccccc1/C(=N\OC)C(=O)OC)\c1ccc(OC(C)c2ccc(Cl)cc2)cc1

nearest known ligand 0.49

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
HIF1A Q16665 8/20 0.49
LTB4R Q15722 6/20 0.35
LTB4R2 Q9NPC1 6/20 0.35
PTGS2 P35354 1/20 0.32
UTS2R Q9UKP6 1/20 0.32
PPARG P37231 1/20 0.32
PPARA Q07869 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8030802 0.92 HIF1A (0.40) HIF1ALTB4RLTB4R2PTGS2UTS2R
SCHEMBL7868781 0.88 HIF1A (0.36) HIF1ALTB4RLTB4R2PTGS2
SCHEMBL7127227 0.86 HIF1A (0.59) HIF1APTGS2
SCHEMBL7127228 0.86 HIF1A (0.59) HIF1APTGS2
SCHEMBL8543770 0.82 HIF1A (0.51) HIF1A
SCHEMBL17949971 0.81 HIF1A (0.45) HIF1APTGS2
SCHEMBL7495777 0.81 HIF1A (0.44) HIF1APTGS2UTS2R
SCHEMBL7500390 0.78 HIF1A (0.54) HIF1A
SCHEMBL23972094 0.78 HIF1A (0.60) HIF1APPARGPPARA
SCHEMBL7716053 0.77 HIF1A (0.48) HIF1APTGS2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6313344-B1 PESTICIDES BAYER AKTIENGESELLSCHAFT (DE) 2001-11-06 US disclosed
EP-0984923-A1 O-BENZYL OXIME ETHERS AND THEIR USE AS PESTICIDES Novartis AG (CH) 2000-03-15 EP disclosed
WO-1998054125-A1 O-BENZYL OXIME ETHERS AND THEIR USE AS PESTICIDES NOVARTIS AG (CH) 1998-12-03 WO disclosed