SCHEMBL8543770

SCHEMBL8543770

CCCOc1ccc(C(=NOC)C(C)=NOCc2ccccc2C(=NOCC)C(=O)OC)cc1

nearest known ligand 0.51

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
HIF1A Q16665 8/20 0.51
MEN1 O00255 2/20 0.36
KMT2A Q03164 2/20 0.36
POLB P06746 1/20 0.36
PLK1 P53350 2/20 0.36
SMN1; SMN2 Q16637 2/20 0.35
MAPT P10636 2/20 0.35
RAB9A P51151 2/20 0.35
NPC1 O15118 1/20 0.35
NFKB1 P19838 1/20 0.35
NFKB2 Q00653 1/20 0.35
RELA Q04206 1/20 0.35
KDM4E B2RXH2 1/20 0.35
HTT P42858 1/20 0.35
FAAH O00519 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7500390 0.96 HIF1A (0.54) HIF1AMEN1KMT2APOLBPLK1
SCHEMBL8538327 0.90 HIF1A (0.51) HIF1AMAPT
SCHEMBL7505105 0.87 HIF1A (0.43) HIF1AMEN1KMT2APOLBPLK1
SCHEMBL7494756 0.85 HIF1A (0.54) HIF1AMAPTL3MBTL1
SCHEMBL7501613 0.84 HIF1A (0.54) HIF1A
SCHEMBL7863529 0.84 HIF1A (0.44) HIF1ASMN1; SMN2KDM4E
SCHEMBL7127228 0.83 HIF1A (0.59) HIF1AMEN1KMT2ASMN1; SMN2MAPT
SCHEMBL7127227 0.83 HIF1A (0.59) HIF1AMEN1KMT2ASMN1; SMN2MAPT
SCHEMBL7495586 0.83 HIF1A (0.43) HIF1AMEN1KMT2APLK1MAPT
SCHEMBL7468302 0.83 HIF1A (0.60) HIF1AMAPTHTTL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0865424-A1 PESTICIDES Novartis AG (CH) 1998-09-23 EP disclosed
WO-1997020809-A1 PESTICIDES NOVARTIS AG (CH) 1997-06-12 WO disclosed