Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | CARM1 | Q86X55 | 3/20 | 0.38 |
| ▸ | PRMT1 | Q99873 | 3/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.35 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.35 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.35 |
| ▸ | KDM4A | O75164 | 1/20 | 0.35 |
| ▸ | KDM4B | O94953 | 1/20 | 0.35 |
| ▸ | KDM5C | P41229 | 1/20 | 0.35 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.33 |
| ▸ | PDE2A | O00408 | 1/20 | 0.33 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27803026 | 0.84 | CARM1 (0.40) | ESR1CARM1PRMT1CHEK2PARP1 | |
| SCHEMBL7855710 | 0.80 | HCRTR1 (0.43) | ESR1CHEK2PARP1KDM4AKDM4B | |
| SCHEMBL8220811 | 0.78 | HRH3 (0.48) | CARM1PRMT1CHEK2PARP1ADRB2 | |
| SCHEMBL19268046 | 0.78 | CARM1 (0.40) | ESR1CARM1PRMT1CHEK2PARP1 | |
| SCHEMBL1259158 | 0.78 | CARM1 (0.40) | ESR1CARM1PRMT1CHEK2PARP1 | |
| SCHEMBL533611 | 0.78 | FYN (0.45) | ESR1CARM1PRMT1CHEK2PARP1 | |
| SCHEMBL534208 | 0.78 | ESR1 (0.42) | ESR1CHEK2PARP1ADRB2ADRB1 | |
| SCHEMBL8233552 | 0.78 | METAP2 (0.44) | ESR1CARM1PRMT1KDM4ENPC1 | |
| SCHEMBL17440027 | 0.78 | CARM1 (0.40) | ESR1CARM1PRMT1CHEK2PARP1 | |
| SCHEMBL7855627 | 0.77 | SCN9A (0.35) | ESR1CARM1PRMT1CHEK2PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1086097-A1 | SULFONYLBENZENE COMPOUNDS AS ANTI-INFLAMMATORY/ANALGESIC AGENTS | PFIZER INC. (US) | 2001-03-28 | — | — | EP | disclosed |
| WO-1999064415-A1 | SULFONYLBENZENE COMPOUNDS AS ANTI-INFLAMMATORY/ANALGESIC AGENTS | PFIZER PHARMACEUTICALS INC. (JP) | 1999-12-16 | — | — | WO | disclosed |