Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | RAF1 | P04049 | 1/20 | 0.41 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7867003 | 0.95 | KDM4E (0.42) | KDM4ECYP1A2TDP1HIF1AMEN1 | |
| SCHEMBL7864548 | 0.95 | HCRTR1 (0.42) | KDM4ECYP1A2TDP1HIF1AMEN1 | |
| SCHEMBL7864551 | 0.90 | CA14 (0.48) | KDM4ETDP1CA14CYP3A4 | |
| SCHEMBL7866979 | 0.89 | CA14 (0.49) | KDM4ETDP1CA14SMN1; SMN2CYP3A4 | |
| SCHEMBL15311807 | 0.85 | CYP1A2 (0.47) | KDM4ECYP1A2TDP1HIF1AMEN1 | |
| SCHEMBL15311805 | 0.85 | CYP1A2 (0.47) | KDM4ECYP1A2TDP1HIF1AMEN1 | |
| SCHEMBL15311416 | 0.84 | CYP1A2 (0.46) | KDM4ECYP1A2TDP1HIF1AMEN1 | |
| SCHEMBL15311414 | 0.84 | CYP1A2 (0.46) | KDM4ECYP1A2TDP1HIF1AMEN1 | |
| SCHEMBL5073353 | 0.84 | HIF1A (0.55) | KDM4ECYP1A2TDP1HIF1AMEN1 | |
| SCHEMBL8610350 | 0.83 | KDM4E (0.45) | KDM4ECYP1A2TDP1HIF1AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0815081-B1 | PIPERIDINYL-2-ALKYL SUBSTITUTED LINEAR POLYAMINES FOR THE REDUCTION OF INTRACELLULAR, ENDOGENIC POLYAMINE LEVELS SUCH AS PUTRESCINE, SPERMIDINE AND SPERMINE, AND THEIR IMPACT ON CELL PROLIFERATION | NOVARTIS AG (CH) | 2001-10-04 | — | — | EP | disclosed |
| EP-0815081-A1 | PIPERIDINYL-2-ALKYL SUBST. LINEAR POLYAMINES FOR THE REDUCTION OF INTRACELLULAR, ENDOGENIC POLYAMINE LEVELS SUCH AS PUTRESCINE, SPERMIDINE AND SPERMINE, AND THEIR IMPACT ON CELL PROLIFERATION | Novartis AG (CH) | 1998-01-07 | — | — | EP | disclosed |
| WO-1996028425-A1 | PIPERIDINYL-2-ALKYL SUBST. LINEAR POLYAMINES FOR THE REDUCTION OF INTRACELLULAR, ENDOGENIC POLYAMINE LEVELS SUCH AS PUTRESCINE, SPERMIDINE AND SPERMINE, AND THEIR IMPACT ON CELL PROLIFERATION | NOVARTIS AG (CH) | 1996-09-19 | — | — | WO | disclosed |