Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 12/20 | 0.42 |
| ▸ | HCRTR2 | O43614 | 12/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7864555 | 0.95 | KDM4E (0.45) | KDM4ETDP1ALDH1A1CYP1A2HIF1A | |
| SCHEMBL7867003 | 0.93 | KDM4E (0.42) | HCRTR1HCRTR2KDM4ETDP1ALDH1A1 | |
| SCHEMBL7864551 | 0.85 | CA14 (0.48) | KDM4ETDP1 | |
| SCHEMBL7866979 | 0.84 | CA14 (0.49) | KDM4ETDP1 | |
| SCHEMBL27439189 | 0.82 | TRPM8 (0.55) | KDM4ETDP1CYP1A2TRPM8 | |
| SCHEMBL8610350 | 0.81 | KDM4E (0.45) | HCRTR1HCRTR2KDM4ETDP1ALDH1A1 | |
| SCHEMBL15311807 | 0.81 | CYP1A2 (0.47) | KDM4ETDP1ALDH1A1CYP1A2HIF1A | |
| SCHEMBL15311805 | 0.81 | CYP1A2 (0.47) | KDM4ETDP1ALDH1A1CYP1A2HIF1A | |
| SCHEMBL15311416 | 0.80 | CYP1A2 (0.46) | KDM4ETDP1ALDH1A1CYP1A2HIF1A | |
| SCHEMBL15311414 | 0.80 | CYP1A2 (0.46) | KDM4ETDP1ALDH1A1CYP1A2HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0815081-B1 | PIPERIDINYL-2-ALKYL SUBSTITUTED LINEAR POLYAMINES FOR THE REDUCTION OF INTRACELLULAR, ENDOGENIC POLYAMINE LEVELS SUCH AS PUTRESCINE, SPERMIDINE AND SPERMINE, AND THEIR IMPACT ON CELL PROLIFERATION | NOVARTIS AG (CH) | 2001-10-04 | — | — | EP | disclosed |
| US-5834486-A | ANTIPROLIFERATIVE, ANTIPROTOZOA AGENTS | NOVARTIS AG (CH) | 1998-11-10 | — | — | US | disclosed |
| EP-0815081-A1 | PIPERIDINYL-2-ALKYL SUBST. LINEAR POLYAMINES FOR THE REDUCTION OF INTRACELLULAR, ENDOGENIC POLYAMINE LEVELS SUCH AS PUTRESCINE, SPERMIDINE AND SPERMINE, AND THEIR IMPACT ON CELL PROLIFERATION | Novartis AG (CH) | 1998-01-07 | — | — | EP | disclosed |
| WO-1996028425-A1 | PIPERIDINYL-2-ALKYL SUBST. LINEAR POLYAMINES FOR THE REDUCTION OF INTRACELLULAR, ENDOGENIC POLYAMINE LEVELS SUCH AS PUTRESCINE, SPERMIDINE AND SPERMINE, AND THEIR IMPACT ON CELL PROLIFERATION | NOVARTIS AG (CH) | 1996-09-19 | — | — | WO | disclosed |