Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 16/20 | 0.90 |
| ▸ | EGFR | P00533 | 15/20 | 0.90 |
| ▸ | FGFR1 | P11362 | 12/20 | 0.90 |
| ▸ | FLT1 | P17948 | 12/20 | 0.90 |
| ▸ | FLT4 | P35916 | 11/20 | 0.90 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.74 |
| ▸ | RET | P07949 | 3/20 | 0.74 |
| ▸ | TEK | Q02763 | 2/20 | 0.74 |
| ▸ | KIF5B | P33176 | 2/20 | 0.74 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.74 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.74 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.74 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.74 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.74 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.74 |
| ▸ | PLK4 | O00444 | 1/20 | 0.74 |
| ▸ | CIT | O14578 | 1/20 | 0.74 |
| ▸ | GAK | O14976 | 1/20 | 0.74 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.74 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7866132 | 0.99 | EGFR (0.92) | KDREGFRFGFR1FLT1FLT4 | |
| Hydrochloric Acid SCHEMBL27218174 | 0.95 | EGFR (1.00) | KDREGFRFGFR1FLT1FLT4 | |
| SCHEMBL17520347 | 0.94 | KDR (0.82) | KDREGFRFGFR1FLT1FLT4 | |
| SCHEMBL7859476 | 0.91 | KDR (0.83) | KDREGFRFGFR1FLT1FLT4 | |
| Hydrochloric Acid SCHEMBL7870588 | 0.91 | EGFR (0.81) | KDREGFRFGFR1FLT1FLT4 | |
| SCHEMBL7864669 | 0.90 | KDR (1.00) | KDREGFRFGFR1FLT1FLT4 | |
| SCHEMBL17520359 | 0.89 | KDR (0.87) | KDREGFRFGFR1FLT1FLT4 | |
| SCHEMBL17520326 | 0.89 | EGFR (0.85) | KDREGFRFGFR1FLT1FLT4 | |
| SCHEMBL17520350 | 0.89 | KDR (0.82) | KDREGFRFGFR1FLT1FLT4 | |
| SCHEMBL1467784 | 0.87 | KDR (0.83) | KDREGFRFGFR1FLT1FLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0885198-B1 | 4-ANILINOQUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2001-12-19 | — | — | EP | claimed |
| US-6291455-B1 | PRODUCING AN ANTIANGIOGENIC AND/OR VASCULAR PERMEABILITY REDUCING EFFECT | ZENECA LIMITED (GB) | 2001-09-18 | — | — | US | claimed |
| EP-0885198-A1 | 4-ANILINOQUINAZOLINE DERIVATIVES | ZENECA LIMITED (GB) | 1998-12-23 | — | — | EP | claimed |
| WO-1997032856-A1 | 4-ANILINOQUINAZOLINE DERIVATIVES | ZENECA LIMITED (GB) | 1997-09-12 | — | — | WO | claimed |
| EP-0885198-B1 | 4-ANILINOQUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2001-12-19 | — | — | EP | disclosed |
| US-6291455-B1 | PRODUCING AN ANTIANGIOGENIC AND/OR VASCULAR PERMEABILITY REDUCING EFFECT | ZENECA LIMITED (GB) | 2001-09-18 | — | — | US | disclosed |
| EP-0885198-A1 | 4-ANILINOQUINAZOLINE DERIVATIVES | ZENECA LIMITED (GB) | 1998-12-23 | — | — | EP | disclosed |
| WO-1997032856-A1 | 4-ANILINOQUINAZOLINE DERIVATIVES | ZENECA LIMITED (GB) | 1997-09-12 | — | — | WO | disclosed |