Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.75 |
| ▸ | CTSD | P07339 | 11/20 | 0.60 |
| ▸ | BACE2 | Q9Y5Z0 | 6/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.49 |
| ▸ | REN | P00797 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Formic Acid SCHEMBL2287055 | 0.95 | BACE1 (0.68) | BACE1CTSDBACE2KCNH2REN | |
| SCHEMBL7874076 | 0.91 | BACE1 (0.74) | BACE1CTSDBACE2KCNH2REN | |
| SCHEMBL2283883 | 0.89 | BACE1 (0.61) | BACE1CTSDBACE2KCNH2 | |
| SCHEMBL2283875 | 0.89 | BACE1 (0.61) | BACE1CTSDBACE2KCNH2 | |
| SCHEMBL7870271 | 0.89 | BACE1 (0.76) | BACE1CTSDBACE2KCNH2REN | |
| SCHEMBL2281101 | 0.89 | BACE1 (0.65) | BACE1CTSDBACE2KCNH2 | |
| SCHEMBL2281096 | 0.89 | BACE1 (0.65) | BACE1CTSDBACE2KCNH2 | |
| SCHEMBL2283618 | 0.88 | BACE1 (0.75) | BACE1CTSDBACE2KCNH2REN | |
| SCHEMBL2283615 | 0.88 | BACE1 (0.75) | BACE1CTSDBACE2KCNH2REN | |
| SCHEMBL12376216 | 0.88 | BACE1 (0.71) | BACE1CTSDBACE2KCNH2REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7989449-B2 | 4,5-dihydro-oxazol-2-yl amine derivatives | HOFFMAN-LA ROCHE INC. (US) | 2011-08-02 | — | — | US | disclosed |
| US-7989449-B2 | 4,5-dihydro-oxazol-2-yl amine derivatives | HOFFMAN-LA ROCHE INC. (US) | 2011-08-02 | — | — | US | disclosed |
| WO-2009103626-A1 | 4, 5-DIHYDRO-OXAZOL-2-YL AMINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-08-27 | — | — | WO | disclosed |
| US-20090209529-A1 | 4,5-DIHYDRO-OXAZOL-2-YL AMINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-08-20 | — | — | US | disclosed |
| US-20090209529-A1 | 4,5-DIHYDRO-OXAZOL-2-YL AMINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-08-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090209529-A1 | 4,5-DIHYDRO-OXAZOL-2-YL AMINE DERIVATIVES | BACE2, BACE1, PSEN2 | BACE1 2/4885CTSD 721/4885BACE2 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.